Document Detail


Extracorporeal artificial liver support systems in the management of intractable cholestatic pruritus.
MedLine Citation:
PMID:  21824282     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Pruritus can occur as a severe complication of cholestasis. Several hypotheses suggest an important role for the accumulation of bile acids, endogenous opioids and - mire recently - lysophosphatidic acid. Bile acid sequestrants are the first-line therapeutic agents. In refractory cases, a stepwise approach using rifampicin, oral opiate antagonists and the selective serotonine reuptake inhibitor sertraline should be tested. Recent case series reported effective relief of pruritus using extracorporal liver support systems and plasmapheresis.
Authors:
Valentin Fuhrmann; Andreas Drolz; Michael Trauner
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Liver international : official journal of the International Association for the Study of the Liver     Volume:  31 Suppl 3     ISSN:  1478-3231     ISO Abbreviation:  Liver Int.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101160857     Medline TA:  Liver Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  31-3     Citation Subset:  IM    
Copyright Information:
© 2011 John Wiley & Sons A/S.
Affiliation:
Department of Internal Medicine 3, Division of Gastroenterology and Hepatology, Medical University Vienna, Vienna, Austria.
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