Document Detail

Extracorporeal adsorption as a new approach to treatment of botulism.
MedLine Citation:
PMID:  11110282     Owner:  NLM     Status:  MEDLINE    
Botulism is a paralytic disease caused by a toxin produced by the bacterium Clostridium botulinum. Outbreaks of the illness take place with a mortality rate of 10%, and the potential terrorist use of the toxin has become a serious concern. The current treatment includes administration of antitoxin, which can cause serious allergic reactions. Recently, we have successfully treated a 64 year old woman with the illness with IMMUSORBA TR350 (Asahi Medical, Tokyo, Japan), an extracorporeal adsorptive column containing polyvinylalcohol-tryptophan as an adsorptive agent, which has been widely used in Japan to treat myasthenia gravis and Guillain-Barre syndrome. Initially, the patient developed ocular muscle weakness and a variant of the Guillain-Barre syndrome was suspected. After extracorporeal treatment, her neurologic symptoms remarkably improved. After a series of treatments, botulinum toxin type B was isolated in the food she had eaten, establishing the diagnosis. An in vitro study revealed that the adsorptive column removed botulinum toxin to a significant extent. Our recent findings suggest that treatment with the adsorptive column TR350 can be a feasible option for botulism, which is a rare but potentially lethal disease.
Y Sato; N Kimata; S Miyahara; H Nihei; T Agishi; M Takahashi
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  46     ISSN:  1058-2916     ISO Abbreviation:  ASAIO J.     Publication Date:    2000 Nov-Dec
Date Detail:
Created Date:  2001-03-01     Completed Date:  2001-04-12     Revised Date:  2013-11-25    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  783-5     Citation Subset:  IM    
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MeSH Terms
Botulinum Toxins / blood,  isolation & purification*
Botulism / blood,  therapy*
Extracorporeal Circulation / methods
Immunosorbent Techniques
Middle Aged
Plasmapheresis / methods
Reg. No./Substance:
0Y70779M1F/rimabotulinumtoxinB; EC Toxins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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