Document Detail

Extracorporeal fluid removal in heart failure patients.
MedLine Citation:
PMID:  20427974     Owner:  NLM     Status:  MEDLINE    
Ultrafiltration is the mechanical removal of fluid from the vasculature. Hydrostatic pressure is applied to blood across a semipermeable membrane to separate isotonic plasma water from blood. Because solutes in blood freely cross the semipermeable membrane, large amounts of fluid can be removed at the discretion of the treating physician without affecting any change in the serum concentration of electrolytes and other solutes. Ultrafiltration has been used to relieve congestion in patients with heart failure for almost four decades. In contrast to the adverse physiological consequences of loop diuretics, numerous studies have demonstrated favorable responses to ultrafiltration. Such studies have shown that removal of large amounts of isotonic fluid relieves symptoms of congestion, improves exercise capacity, improves cardiac filling pressures, restores diuretic responsiveness in patients with diuretic resistance, and has a favorable effect on pulmonary function, ventilatory efficiency, and neurohormonal activation. Ultrafiltration is the only fluid removal strategy shown to improve outcomes in randomized controlled trials of patients hospitalized with decompensated heart failure.
Maria Rosa Costanzo; Claudio Ronco
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Publication Detail:
Type:  Journal Article     Date:  2010-04-20
Journal Detail:
Title:  Contributions to nephrology     Volume:  165     ISSN:  1662-2782     ISO Abbreviation:  Contrib Nephrol     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-29     Completed Date:  2010-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513582     Medline TA:  Contrib Nephrol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  236-43     Citation Subset:  IM    
Copyright Information:
2010 S. Karger AG, Basel.
Midwest Heart Foundation, Naperville, Ill., USA.
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MeSH Terms
Cardiotonic Agents / therapeutic use
Diuretics / therapeutic use*
Heart Failure / drug therapy,  physiopathology,  therapy*
Hydrostatic Pressure
Treatment Failure
Treatment Outcome
Ultrafiltration / adverse effects,  methods*
Vasodilator Agents / therapeutic use
Reg. No./Substance:
0/Cardiotonic Agents; 0/Diuretics; 0/Vasodilator Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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