Document Detail

Extracellular water: sodium bromide dilution estimates compared with other markers in patients with acquired immunodeficiency syndrome.
MedLine Citation:
PMID:  10081994     Owner:  NLM     Status:  MEDLINE    
Extracellular fluid and closely related extracellular water (ECW) provide information on nutritional status in health and disease. Although various methods exist for ECW determination, little is known about their comparability in patients with wasting diseases such as acquired immunodeficiency syndrome (AIDS). One practical method, the dilution of sodium bromide (NaBr), is used widely in clinical research, although its relationship to other ECW markers has not been well characterized. The present study sought to compare ECW estimates as determined by NaBr and three other methods in 11 male patients with AIDS (mean +/- SD; age, 44+/-12 years; body weight, 64.5+/-8.8 kg; and height, 172+/-4 cm). ECW volumes were determined from NaBr dilution, total body chlorine (TBCl) by delayed gamma-neutron activation analysis, total body water (TBW) by tritium dilution combined with total body potassium (TBK) by whole body 40K counting, and radioactive sulfate dilution (35SO4). All correlations between the NaBr method and other methods were statistically significant (NaBr vs TBCl [r = .91; p < .001]; vs TBW/TBK [r = .76; p < .01]; and vs 35SO4 [r = .89; p < .001]). As expected from previous studies, ECW (L) derived by NaBr provided a group mean (15.1+/-2.2 L) similar to the TBCl method (15.4+/-1.7 L; p = .32), a significantly smaller ECW than by the TBW/TBK method (18.6+/-3.4 L; p = .0004), and a significantly larger ECW than by 35SO4 method (13.3+/-3.0 L; p = .002). Estimating ECW by NaBr dilution was comparable with other research-based ECW methods and, thus, offers a practical alternative for evaluating ECW in patients with AIDS.
J Kim; Z Wang; D Gallagher; D P Kotler; K Ma; S B Heymsfield
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  JPEN. Journal of parenteral and enteral nutrition     Volume:  23     ISSN:  0148-6071     ISO Abbreviation:  JPEN J Parenter Enteral Nutr     Publication Date:    1999 Mar-Apr
Date Detail:
Created Date:  1999-04-29     Completed Date:  1999-04-29     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  7804134     Medline TA:  JPEN J Parenter Enteral Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  61-6     Citation Subset:  IM; X    
Obesity Research Center and Body Composition Unit, St Luke's/Roosevelt Hospital, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
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MeSH Terms
Acquired Immunodeficiency Syndrome / physiopathology*
Body Mass Index
Body Water*
Bromides / analysis*
Chlorine / analysis
Extracellular Space*
Indicator Dilution Techniques*
Middle Aged
Neutron Activation Analysis
Potassium / analysis,  blood
Potassium Radioisotopes
Serum Albumin / analysis
Sodium / blood
Sodium Compounds / analysis*
Sulfur Radioisotopes
Reg. No./Substance:
0/Bromides; 0/Potassium Radioisotopes; 0/Serum Albumin; 0/Sodium Compounds; 0/Sulfates; 0/Sulfur Radioisotopes; 10028-17-8/Tritium; 7440-09-7/Potassium; 7440-23-5/Sodium; 7647-15-6/sodium bromide; 7782-50-5/Chlorine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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