Document Detail


Extracellular vesicles: emerging targets for cancer therapy.
MedLine Citation:
PMID:  24703619     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are released by almost all cell types, including tumour cells. Through transfer of their molecular contents, EVs are capable of altering the function of recipient cells. Increasing evidence suggests a key role for EV mediated intercellular communication in a variety of cellular processes involved in tumour development and progression, including immune suppression, angiogenesis, and metastasis. Aspects of EV biogenesis or function are therefore increasingly being considered as targets for anticancer therapy. Here, we summarise the current knowledge on the contributions of EVs to cancer pathogenesis and discuss novel therapeutic strategies to target EVs to prevent tumour growth and spread.
Authors:
Pieter Vader; Xandra O Breakefield; Matthew J A Wood
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Publication Detail:
Type:  REVIEW     Date:  2014-4-2
Journal Detail:
Title:  Trends in molecular medicine     Volume:  -     ISSN:  1471-499X     ISO Abbreviation:  Trends Mol Med     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966035     Medline TA:  Trends Mol Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ltd. All rights reserved.
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