Document Detail


Extracellular thioredoxin and thioredoxin-binding protein 2 in control of cancer.
MedLine Citation:
PMID:  17095246     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thioredoxin-1 (TRX) is a redox-active protein with multiple intracellular and extracellular functions. Intracellular redox balance is maintained by the TRX family and its related molecules. Extracellular TRX shows cytoprotective effects, while truncated Trx80 has more mitogenic activity. Exogenously administered TRX does not promote the growth of cancer in vivo and shows anti-chemotactic effect for neutrophils and anti-inflammatory functions. Thioredoxin is released from cells in response to oxidative stress and TRX levels in plasma or serum are good markers for oxidative stress associated with cancer. Thioredoxin-binding protein 2 (TBP-2) is an endogenous negative regulator of TRX and a tumor suppressor.
Authors:
Hajime Nakamura; Hiroshi Masutani; Junji Yodoi
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-09-26
Journal Detail:
Title:  Seminars in cancer biology     Volume:  16     ISSN:  1044-579X     ISO Abbreviation:  Semin. Cancer Biol.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-27     Completed Date:  2007-01-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9010218     Medline TA:  Semin Cancer Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  444-51     Citation Subset:  IM    
Affiliation:
Department of Experimental Therapeutics, Translational Research Center, Kyoto University Hospital, Kyoto 606-8507, Japan. hnakamur@kuhp.kyoto-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Carrier Proteins / metabolism*
Humans
Neoplasms / prevention & control*
Oxidation-Reduction
Thioredoxins / metabolism*
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/TXNIP protein, human; 52500-60-4/Thioredoxins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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