| Extracellular targeting of synthetic therapeutic nucleic acid formulations. | |
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MedLine Citation:
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PMID: 18855630 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Success of nucleic acid based therapies often depends on target-cell specific delivery of genetic materials such as plasmid DNA, antisense oligonucleotides or small interfering RNA. Such extracellular targeting strategies include the incorporation of hydrophilic shielding domains into nucleic acid carriers which protects them from unspecific interactions with non-target tissues (passive targeting), and the inclusion of targeting moieties which allows recognition of target-specific cellular receptors (active targeting). Furthermore physical targeting methods such as magnetofection, electroporation or by photochemical means have been used to enhance efficiency of nucleic acid transfer. For optimum efficacy, extracellular targeting concepts are combined with programmed bioresponsive carrier chemistry which confers to the formulation stability during extracellular delivery but controlled disassembly and nucleic acid release after reaching the target cell. |
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Authors:
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Alexander Philipp; Martin Meyer; Ernst Wagner |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current gene therapy Volume: 8 ISSN: 1566-5232 ISO Abbreviation: Curr Gene Ther Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-15 Completed Date: 2009-02-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101125446 Medline TA: Curr Gene Ther Country: Netherlands |
Other Details:
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Languages: eng Pagination: 324-34 Citation Subset: IM |
Affiliation:
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Pharmaceutical Biotechnology, Center for Drug Research, Department of Pharmacy, Ludwig-Maximilians-Universität, Butenandstr. 5-13, D-81377 Munich, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chemistry, Pharmaceutical Drug Delivery Systems Extracellular Space / genetics* Gene Therapy / methods* Hepatocytes / metabolism Humans Leukocytes / metabolism Neoplasms / genetics, therapy Neurons / metabolism Nucleic Acids / administration & dosage*, genetics* Photochemistry |
| Chemical | |
Reg. No./Substance:
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0/Nucleic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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