Document Detail

Extracellular matrix turnover and inflammatory markers independently predict functional status and outcome in chronic heart failure.
MedLine Citation:
PMID:  18672194     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Inflammatory pathways may promote extracellular matrix (ECM) remodeling and chronic heart failure (CHF) progression. The relationship between markers of inflammation and of ECM remodeling, and their influence on functional status and outcomes has not been examined in a large cohort of CHF patients. METHODS AND RESULTS: We measured baseline blood serum collagen (amino-terminal propeptide of collagen III [PIIINP], metalloproteinase 1 [MMP-1], tissue inhibitor of metalloproteinase 1 [TIMP-1]), and inflammatory (high-sensitivity C-reactive protein [(hsCRP], interleukin [IL]-18, IL-10) markers in 1009 patients enrolled in the Research into Etanercept Cytokine Antagonism in Ventricular Dysfunction (RECOVER) trial. A positive correlation was detected between the 2 classes of markers (PIIINP to IL-18, MMP-1 and TIMP-1 to CRP, TIMP-1 to IL-18, MMP-1 to IL-10). In the adjusted multivariable model including all biomarkers, only PIIINP (P = .03) and MMP-1 (P = .048) were independent predictors of 6-minute walk test (6-MWT), whereas in another model including only inflammatory biomarkers, IL-18 was an independent predictor. PIIINP (P = .001) was the only biomarker independently associated with death and CHF hospitalization. CONCLUSIONS: The independent associations of PIIINP and MMP-1 with 6-MWT and PIIINP with CHF morbi-mortality suggest that excessive ECM turnover may be associated with functional capacity deterioration and poor outcome.
Anca Radauceanu; Camille Ducki; Jean-Marc Virion; Patrick Rossignol; Ziad Mallat; John McMurray; Dirk J Van Veldhuisen; Luigi Tavazzi; Douglas L Mann; Josette Capiaumont-Vin; Minjiang Li; Didier Hanriot; Faiez Zannad
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-05-27
Journal Detail:
Title:  Journal of cardiac failure     Volume:  14     ISSN:  1532-8414     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-01     Completed Date:  2009-02-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  467-74     Citation Subset:  IM    
Centre d'Investigation Clinique 9501, INSERM, Dommartin-lès-Toul, France.
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MeSH Terms
Biological Markers / blood
Chronic Disease
Cohort Studies
Double-Blind Method
Extracellular Matrix / metabolism*,  pathology
Heart Failure / mortality*,  pathology*,  therapy
Inflammation Mediators / physiology*
Middle Aged
Predictive Value of Tests
Survival Rate / trends
Treatment Outcome
Reg. No./Substance:
0/Biological Markers; 0/Inflammation Mediators

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