| Extracellular matrix remodelling in rat endometrium during early pregnancy: the role of fibronectin and laminin. | |
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MedLine Citation:
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PMID: 20810141 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The endometrial extracellular matrix (ECM) remodelling has a crucial role in the establishment of a successful pregnancy. In addition to its basic function such as regulation of cell function, differentiation, migration, proliferation, the substantial alterations in the endometrial ECM may play a specific role in the trophoblast invasion, placentation, cell death and formation of the proper and functional implantation chamber around the embryo. In the present study, immunolocalizations of fibronectin and laminin were determined using avidin-biotin complex-peroxidase in rat implantation sites during 7-10 days of pregnancy. Both proteins were present in the basal membrane of blood vessels and in decidual matrix whereas they were absent or had very weak reactivity in the primary decidual zone on day 7. When placentation has begun, the immunoreactivity of both proteins was increased in the placental bed and in the basal membrane of blood vessels of the mesometrial region. The immunolocalization of both proteins seemed to be decreased in the antimesometrial decidua, however, it was increased in the mesometrial decidual matrix on days 9 and 10. Therefore, it could be suggested laminin and fibronectin demonstrating dynamic expressions in relation with the morphological differentiation of endometrial stroma may play crucial roles in the control of trophoblast adhesion and invasion, in placentation and angiogenesis, in the determination of cell shape and fate thus contributing the endometrial receptivity and a successful pregnancy. |
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Authors:
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Celal Kaloglu; Bilge Onarlioglu |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Tissue & cell Volume: 42 ISSN: 1532-3072 ISO Abbreviation: Tissue Cell Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2011-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0214745 Medline TA: Tissue Cell Country: Scotland |
Other Details:
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Languages: eng Pagination: 301-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Histology and Embryology, Cumhuriyet University, Faculty of Medicine, 58140 Sivas, Turkey. ckaloglu@cumhuriyet.edu.tr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Embryo Implantation / physiology* Endometrium / cytology* Extracellular Matrix / physiology* Female Fibronectins / physiology* Laminin / physiology* Pregnancy Pregnancy, Animal / physiology* Rats |
| Chemical | |
Reg. No./Substance:
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0/Fibronectins; 0/Laminin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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