Document Detail

Extracellular matrix metalloproteinase inducer in interstitial pneumonias.
MedLine Citation:
PMID:  16867869     Owner:  NLM     Status:  MEDLINE    
Extracellular matrix metalloproteinase inducer (EMMPRIN), a glycosylated transmembrane protein that induces matrix metalloproteinases (MMPs), is minimally expressed in the normal adult lung. We previously reported that it is up-regulated in murine bleomycin-induced lung injury. In this study, we determined the expression of EMMPRIN and its association with MMP-2, MMP-7, and MMP-9 in interstitial pneumonias (IPs). We performed immunohistochemistry for EMMPRIN and MMPs on lung tissue from 22 subjects with various IPs. We did bronchoalveolar lavage (BAL) on 9 of these subjects and 13 others with IPs to measure the soluble EMMPRIN in BAL fluid. For comparison, immunohistochemistry or BAL was done on 14 subjects without IPs. The staining intensity for each protein was scored from 0 to 3 in various epithelial cell types. Soluble EMMPRIN in BAL fluid was measured by an enzyme-linked immunosorbent assay. Extracellular matrix metalloproteinase inducer was prominent in abnormal epithelial cells. It was more prominent in hyperplastic type II cells, compared with epithelium in alveolar bronchiolization. It was also elevated in BAL fluid from the subjects with IPs. Matrix metalloproteinases were expressed in cells expressing EMMPRIN, although the profile of MMPs varied among the different abnormal epithelial cell types with MMP-2 and MMP-7 in hyperplastic type II cells and MMP-7 and MMP-9 in cells showing squamous metaplasia and cells comprising bronchiolization. These results suggest a role of EMMPRIN in reepithelialization in IPs.
Nao Odajima; Tomoko Betsuyaku; Yasuyuki Nasuhara; Tomoo Itoh; Yuh Fukuda; Robert M Senior; Masaharu Nishimura
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-06-02
Journal Detail:
Title:  Human pathology     Volume:  37     ISSN:  0046-8177     ISO Abbreviation:  Hum. Pathol.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-26     Completed Date:  2006-09-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1058-65     Citation Subset:  IM    
First Department of Medicine, Hokkaido University Hospital, Sapporo 060-8638, Japan.
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MeSH Terms
Antigens, CD147 / metabolism*
Bronchoalveolar Lavage
Bronchoalveolar Lavage Fluid / chemistry
Epithelial Cells / metabolism,  pathology
Lung / metabolism*,  pathology
Lung Diseases, Interstitial / metabolism*,  pathology
Matrix Metalloproteinases / metabolism
Middle Aged
Grant Support
Reg. No./Substance:
136894-56-9/Antigens, CD147; EC 3.4.24.-/Matrix Metalloproteinases

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