| Extracellular matrix and left ventricular mechanics in overload hypertrophy. | |
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MedLine Citation:
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PMID: 17582942 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In all conditions altering wall stress and mechanical stretching, LV performance becomes insufficient at the distance, due to a number of structural and functional alterations ultimately impairing pump function, but not invariably due to reduced inotropic state. Among them, structural alteration of the normal myocardial architectures might play a key role to explain the early events of cardiac dysfunction. Abnormalities of the collagen scaffold facilitate alteration of the physiological orientation of muscular fibers and consequent impaired transmission of the contraction force through the myocardial wall toward the endocardium. Further adaptations are promoted by neurohormonal activation eventually yielding abnormal gene expression of contractile proteins. In the alterations of normal myocardial architecture, the turnover of ECM and the architecture of the scaffold is possibly as important as the organization of the cardiomyocyte layers which contributes with their normal orientation to the developed strength at the chamber level. |
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Authors:
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Giovanni de Simone; Oreste de Divitiis |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Advances in clinical pathology : the official journal of Adriatic Society of Pathology Volume: 6 ISSN: 1125-5552 ISO Abbreviation: Adv Clin Path Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2007-06-22 Completed Date: 2007-07-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709997 Medline TA: Adv Clin Path Country: Italy |
Other Details:
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Languages: eng Pagination: 3-10 Citation Subset: IM |
Affiliation:
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Giovanni de Simone Echocardiography Laboratory, Department of Clinical and Experimental Medicine Federico II, University Hospital, School of Medicine, Via S. Pansini 5, 1-80131 Naples, Italy. simogi@unina.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biomechanics Collagen / genetics, metabolism Contractile Proteins / genetics, metabolism Extracellular Matrix / metabolism*, pathology Gene Expression Regulation Humans Hypertrophy, Left Ventricular / pathology, physiopathology* Myocardial Contraction / physiology Myocytes, Cardiac / metabolism, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Contractile Proteins; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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