| Extracellular matrix does not induce the proliferation, but promotes the differentiation, of Hodgkin's cell line HDLM-1. | |
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MedLine Citation:
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PMID: 3565539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tumor cells from the Hodgkin's cell line HDLM-1 were cultured in extracellular matrix (ECM)-coated flasks. Within 24 hours, the cells underwent rapid differentiation, accompanied by morphologic and phenotypic changes. A slow and less prominent, but similar change was observed in HDLM-1 cells after they had been induced with phorbol ester for 5 days. The ECM-induced cells became HeFi-1-negative and expressed antigens 2H9 and 1E9 on their nuclear membranes. These cells had punctate acid-phosphatase and esterase activities. Approximately 70% of the ECM-induced cells were elongated and had long, blunt cytoplasmic projections. These findings, together with evidence the authors previously presented, indicate that H-RS cells are related to interdigitating reticulum cells. The authors believe that the ECM-induced HDLM-1 cells can be used as an important model for studies of the nature and cell lineage of Hodgkin's disease. |
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Authors:
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S M Hsu; X Zhao; P L Hsu; M S Lok |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of pathology Volume: 127 ISSN: 0002-9440 ISO Abbreviation: Am. J. Pathol. Publication Date: 1987 Apr |
Date Detail:
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Created Date: 1987-05-13 Completed Date: 1987-05-13 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0370502 Medline TA: Am J Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 9-14 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, Neoplasm
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analysis Antigens, Surface / analysis Cell Adhesion Cell Cycle Cell Differentiation Cell Division Cells, Cultured Extracellular Matrix / physiology* Hodgkin Disease / immunology, pathology* Humans Nuclear Envelope / immunology Plastics |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Neoplasm; 0/Antigens, Surface; 0/Plastics |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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