Document Detail


Extracellular matrix-derived peptides and myocardial repair.
MedLine Citation:
PMID:  21048428     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Repairing cardiac tissue remains one of the most challenging goals in tissue engineering. Here, we discuss ways whereby we sought to treat myocardial infarctions using extracellular-matrix derived peptides. Using an ischemia/reperfusion myocardial infarction rodent model, we targeted these extracellular matrix-derived peptides to the myocardial infarct site and were able to induce angiogenesis and alter the negative remodeling seen after an acute myocardial infarction. Our results indicate a potentially new strategy for repairing damaged tissue.
Authors:
Shirley S Mihardja; Jiashing Yu; Randall J Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-03-01
Journal Detail:
Title:  Cell adhesion & migration     Volume:  5     ISSN:  1933-6926     ISO Abbreviation:  Cell Adh Migr     Publication Date:    2011 Mar-Apr
Date Detail:
Created Date:  2011-04-11     Completed Date:  2011-08-12     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101469464     Medline TA:  Cell Adh Migr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  111-3     Citation Subset:  IM    
Affiliation:
Cardiovascular Research Institute, University of California-San Francisco, CA, USA.
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MeSH Terms
Descriptor/Qualifier:
Angiogenesis Inducing Agents / administration & dosage,  therapeutic use*
Animals
Antibodies / metabolism
Disease Models, Animal
Extracellular Matrix / chemistry
Extracellular Matrix Proteins / administration & dosage,  chemistry,  therapeutic use*
Immunoconjugates / metabolism
Myocardial Infarction / drug therapy*,  physiopathology
Myocardium / metabolism,  pathology
Peptides / administration & dosage,  chemistry,  therapeutic use*
Rats
Reperfusion Injury / chemically induced,  drug therapy*
Tissue Engineering / methods
Ventricular Remodeling / drug effects
Chemical
Reg. No./Substance:
0/Angiogenesis Inducing Agents; 0/Antibodies; 0/Extracellular Matrix Proteins; 0/Immunoconjugates; 0/Peptides
Comments/Corrections

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