Document Detail

Extracellular matrix composition in chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  22496324     Owner:  NLM     Status:  Publisher    
Extracellular matrix (ECM) composition has an important role in determining airway structure. We postulated that ECM lung composition of COPD patients differs from that observed in smoking and non-smoking subjects without airflow obstruction.We determined the fractional areas of elastic fibres, type-I, III and IV collagen, versican, decorin, biglycan, lumican, fibronectin and tenascin in different compartments of the large and small airways and lung parenchyma in 26 COPD patients, 26 smokers without COPD and 16 non-smoking control subjects.The fractional area of elastic fibres was higher in non-obstructed smokers than in COPD and non-smoking controls, in all lung compartments. Type-I collagen fractional area was lower in the large and small airways of COPD patients and in the small airways of non-obstructed smokers than in non-smokers. Compared with non-smokers, COPD patients had lower versican fractional area in the parenchyma, higher fibronectin fractional area in small airways and higher tenascin fractional area in large and small airways compartments. In COPD patients, significant correlations were found between elastic fibres and fibronectin and lung function parameters.Alterations of the major ECM components are widespread in all lung compartments of patients with COPD and may contribute to persistent airflow obstruction.
Raquel Annoni; Tatiana Lanças; Ryan Yukimatsu Tanigawa; Marcus de Medeiros Matsushita; Sandra de Morais Fernezlian; Andreina Bruno; Luiz Fernando Ferraz da Silva; Peter J Roughley; Salvatore Battaglia; Marisa Dolhnikoff; Pieter S Hiemstra; Peter J Sterk; Klaus F Rabe; Thais Mauad
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-10
Journal Detail:
Title:  The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology     Volume:  -     ISSN:  1399-3003     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
University of Sao Paulo Medical School, Sao Paulo, Brazil.
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