Document Detail

Extracellular matrix changes in the umbilical arteries of growth-restricted fetuses.
MedLine Citation:
PMID:  15846179     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study was undertaken to determine whether the expression of extracellular matrix components (ECM) is altered in the umbilical arteries from preterm fetal growth-restricted (FGR) pregnancies. STUDY DESIGN: Preterm pregnancies with FGR were compared with appropriately grown preterm pregnancies. Umbilical artery messenger RNA (mRNA) levels for fibrillar collagens I and III, nonfibrillar collagen XIV, and decorin were determined by using relative reverse transcriptase polymerase chain reaction (RT-PCR). The mRNA expression was compared between cases and controls by using the Student t test. P < or = .05 was considered significant. RESULTS: Eight FGR cases and 5 control pregnancies were analyzed. Mean counts per minute (cpm) +/- SEM for collagen I and collagen III were increased in FGR pregnancies. There were no differences in mRNA expression of collagen XIV or decorin. CONCLUSION: Increased mRNA expression of collagen I and III, but not collagen XIV or decorin, is found in the umbilical arteries of preterm FGR pregnancies.
Wendy L Kinzler; John C Smulian; C Andrew Kistler; Rita A Hahn; Peihong Zhou; Marion K Gordon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  192     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-22     Completed Date:  2005-05-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1053-9     Citation Subset:  AIM; IM    
Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Maternal Fetal Medicine, UMDNJ-RWJ Medical School, New Brunswick, NJ, USA.
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MeSH Terms
Base Sequence
Case-Control Studies
Collagen Type I / genetics,  metabolism
Collagen Type III / genetics,  metabolism
Extracellular Matrix Proteins / genetics,  metabolism*
Fetal Growth Retardation / physiopathology*,  ultrasonography
Gene Frequency
Genetic Markers / genetics
Gestational Age
Infant, Newborn
Molecular Sequence Data
Non-Fibrillar Collagens / genetics,  metabolism*
Prospective Studies
RNA, Messenger / analysis
Reference Values
Reverse Transcriptase Polymerase Chain Reaction / methods
Sensitivity and Specificity
Ultrasonography, Prenatal
Umbilical Arteries / metabolism*,  pathology
Grant Support
Reg. No./Substance:
0/Collagen Type I; 0/Collagen Type III; 0/Extracellular Matrix Proteins; 0/Genetic Markers; 0/Non-Fibrillar Collagens; 0/RNA, Messenger

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