| Extracellular matrix changes in stented human coronary arteries. | |
| | |
MedLine Citation:
|
PMID: 15302784 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Restenosis after stenting occurs secondary to the accumulation of smooth muscle cells (SMCs) and extracellular matrix (ECM), with the ECM accounting for >50% of the neointimal volume. The composition of the in-stent ECM has not been well characterized in humans. METHODS AND RESULTS: Postmortem human coronary arteries (n=45) containing stents underwent histological assessment of neointimal proteoglycans, hyaluronan, collagen (types I and III), SMCs, and CD44 (a cell surface receptor for hyaluronan). The mean duration of stent implantation was 18.7 months; stents in place > or =3 to <9 months (n=17) were assigned to group 1, stents > or =9 to <18 months old (n=19) to group 2, and stents > or =18 months old (n=9) to group 3. In groups 1 and 2, neointimal versican and hyaluronan staining was strongly positive, colocalized with alpha-actin-positive SMCs, and was greater in intensity compared with group 3. Conversely, decorin staining was greatest in group 3. The neointima of both group 1 and 2 stents was rich in type III collagen, with reduced staining in group 3. Type I collagen staining was weakest in group 1 stents, with progressively stronger staining in groups 2 and 3. SMC density and stent stenosis were significantly reduced in group 3 stents compared with groups 1 and 2. CD44 staining colocalized with macrophages and was associated with increased neointimal thickness. CONCLUSIONS: The ECM within human coronary stents resembles a wound that is not fully healed until 18 months after deployment, followed by neointimal retraction. ECM contraction may be a target for therapies aimed at stent restenosis prevention. |
| | |
Authors:
|
Andrew Farb; Frank D Kolodgie; Jin-Yong Hwang; Allen P Burke; Kirubel Tefera; Deena K Weber; Thomas N Wight; Renu Virmani |
Related Documents
:
|
19944984 - Randomized comparison of nasolacrimal cryoplasty versus plastic lacrimal stenting in th... 7617844 - Superior vena cava stent placement: results with the wallstent endoprosthesis. 9682854 - Surgical treatment of laryngotracheal stenosis: a review of 60 cases. 9068134 - Stenting for abdominal aortic occlusive disease. long-term results. 22052104 - P.o.p.a. study: prevention of postoperative abdominal adhesions by icodextrin 4% soluti... 19665364 - Maternal and neonatal effects of bolus administration of ephedrine and phenylephrine du... |
Publication Detail:
|
Type: Journal Article Date: 2004-08-09 |
Journal Detail:
|
Title: Circulation Volume: 110 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2004 Aug |
Date Detail:
|
Created Date: 2004-08-24 Completed Date: 2005-02-28 Revised Date: 2007-07-25 |
Medline Journal Info:
|
Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
|
Languages: eng Pagination: 940-7 Citation Subset: AIM; IM |
Affiliation:
|
Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Animals Antigens, CD44 / analysis Cell Count Collagen / analysis Coronary Restenosis / metabolism* Extracellular Matrix / chemistry* Extracellular Matrix Proteins Female Humans Hyaluronic Acid / analysis Lectins, C-Type Male Middle Aged Myocytes, Smooth Muscle / pathology Postmortem Changes Protein Isoforms / analysis Proteochondroitin Sulfates / analysis Proteoglycans / analysis Rats Selection Bias Stents* Time Factors Tunica Intima / chemistry Versicans Wound Healing |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, CD44; 0/Cspg2 protein, rat; 0/Extracellular Matrix Proteins; 0/Lectins, C-Type; 0/Protein Isoforms; 0/Proteochondroitin Sulfates; 0/Proteoglycans; 0/VCAN protein, human; 0/decorin; 123939-84-4/biglycan; 126968-45-4/Versicans; 9004-61-9/Hyaluronic Acid; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Angiogenesis and vasculogenesis are impaired in the precocious-aging klotho mouse.
Next Document: Low-dose therapy with the long-acting erythropoietin analogue darbepoetin alpha persistently activat...