| Extracellular matrix and cardiovascular diseases. | |
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MedLine Citation:
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PMID: 8987966 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extracellular matrix (ECM) in the heart and vascular wall includes fibrous proteins and proteoglycans. Fibrous proteins are classified within two categories: structural (collagen and elastin) and adhesive molecules (laminin and fibronectin). These ECM components are important in maintenance of both structure and function of the heart and vascular tissues. Myocardial infarction, hypertrophy, hypertension and heart failure are well known to be associated with progressive cardiac fibrosis. Vascular hypertrophy and thickening has been associated with the pathological series of events that attends both hypertension and restenosis. The accumulation of ECM in the cardiovascular system plays an important role in the development of heart failure after myocardial infarction and hypertension, as well as in vascular hypertrophy and restenosis. Angiotensin II (angiotensin) and transforming growth factor beta 1 are known to play a role in signalling the abnormal accumulation of ECM in these cardiovascular diseases. Administration of angiotensin-converting enzyme inhibitor or angiotensin receptor type 1 antagonist is associated with regression of cardiac hypertrophy and fibrosis as well as vascular hypertrophy. |
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Authors:
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H Ju; I M Dixon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: The Canadian journal of cardiology Volume: 12 ISSN: 0828-282X ISO Abbreviation: Can J Cardiol Publication Date: 1996 Dec |
Date Detail:
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Created Date: 1997-01-22 Completed Date: 1997-01-22 Revised Date: 2008-04-09 |
Medline Journal Info:
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Nlm Unique ID: 8510280 Medline TA: Can J Cardiol Country: CANADA |
Other Details:
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Languages: eng Pagination: 1259-67 Citation Subset: IM |
Affiliation:
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Molecular Cardiology Laboratory, Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, University of Manitoba, Winnipeg. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin I
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antagonists & inhibitors Angiotensin-Converting Enzyme Inhibitors / administration & dosage, pharmacology Cardiomegaly / physiopathology Cardiovascular Diseases / classification, physiopathology* Collagen / metabolism Elastin / metabolism Extracellular Matrix / metabolism* Fibronectins / metabolism Heart Failure / physiopathology Humans Myocardial Infarction / physiopathology Proteoglycans / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Fibronectins; 0/Proteoglycans; 9007-34-5/Collagen; 9007-58-3/Elastin; 9041-90-1/Angiotensin I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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