Document Detail

Extracellular matrix and cardiovascular diseases.
MedLine Citation:
PMID:  8987966     Owner:  NLM     Status:  MEDLINE    
Extracellular matrix (ECM) in the heart and vascular wall includes fibrous proteins and proteoglycans. Fibrous proteins are classified within two categories: structural (collagen and elastin) and adhesive molecules (laminin and fibronectin). These ECM components are important in maintenance of both structure and function of the heart and vascular tissues. Myocardial infarction, hypertrophy, hypertension and heart failure are well known to be associated with progressive cardiac fibrosis. Vascular hypertrophy and thickening has been associated with the pathological series of events that attends both hypertension and restenosis. The accumulation of ECM in the cardiovascular system plays an important role in the development of heart failure after myocardial infarction and hypertension, as well as in vascular hypertrophy and restenosis. Angiotensin II (angiotensin) and transforming growth factor beta 1 are known to play a role in signalling the abnormal accumulation of ECM in these cardiovascular diseases. Administration of angiotensin-converting enzyme inhibitor or angiotensin receptor type 1 antagonist is associated with regression of cardiac hypertrophy and fibrosis as well as vascular hypertrophy.
H Ju; I M Dixon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  12     ISSN:  0828-282X     ISO Abbreviation:  Can J Cardiol     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-01-22     Completed Date:  1997-01-22     Revised Date:  2008-04-09    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1259-67     Citation Subset:  IM    
Molecular Cardiology Laboratory, Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, University of Manitoba, Winnipeg.
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MeSH Terms
Angiotensin I / antagonists & inhibitors
Angiotensin-Converting Enzyme Inhibitors / administration & dosage,  pharmacology
Cardiomegaly / physiopathology
Cardiovascular Diseases / classification,  physiopathology*
Collagen / metabolism
Elastin / metabolism
Extracellular Matrix / metabolism*
Fibronectins / metabolism
Heart Failure / physiopathology
Myocardial Infarction / physiopathology
Proteoglycans / metabolism
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Fibronectins; 0/Proteoglycans; 9007-34-5/Collagen; 9007-58-3/Elastin; 9041-90-1/Angiotensin I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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