| Extracellular matrix and cardiac remodelling. | |
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MedLine Citation:
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PMID: 12611045 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiac remodelling associated with primitive and secondary cardiomyopathy is generally associated with changes in the expression in extracellular matrix (ECM) proteins as well as their transmembrane receptors, the integrins. It emerges now that the ECM provides a structural, chemical, and mechanical substrate that is essential in cardiac function and responses to pathophysiological signals. This review will describe the various elements of the ECM, its modifications that are associated with cardiac hypertrophy and heart failure, and the molecular basis bringing a better insight into the dynamics of the ECM. |
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Authors:
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J K Bendall; C Heymes; P Ratajczak; J L Samuel |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Archives des maladies du coeur et des vaisseaux Volume: 95 ISSN: 0003-9683 ISO Abbreviation: Arch Mal Coeur Vaiss Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2003-03-03 Completed Date: 2003-04-01 Revised Date: 2009-02-13 |
Medline Journal Info:
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Nlm Unique ID: 0406011 Medline TA: Arch Mal Coeur Vaiss Country: France |
Other Details:
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Languages: eng Pagination: 1226-9 Citation Subset: IM |
Affiliation:
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UR572 Inserm, IFR J Marey, hôpital Lariboisière, 41, bd de la Chapelle, 75475 Paris. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cardiomyopathy, Hypertrophic
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physiopathology* Extracellular Matrix Proteins / biosynthesis*, pharmacology Gene Expression Regulation Heart Failure / physiopathology Humans Integrins / biosynthesis Ventricular Remodeling / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Extracellular Matrix Proteins; 0/Integrins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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