| Extracellular lysosome-associated membrane protein-1 (LAMP-1) mediates autoimmune disease progression in the NOD model of type 1 diabetes. | |
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MedLine Citation:
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PMID: 15789355 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Treatment (from 5 to 25 weeks of age) with a novel blocking monoclonal antibody, mAb I-10, directed against the plasma membrane (pm) form of LAMP-1, protected against development of autoimmune diabetes in the NOD mouse. A shorter course of treatment, i.e. from 5 to 12 weeks of age, significantly reduced the occurrence of insulitis as well as disease onset. Interfering with pm-LAMP-1 required continuous treatment as tolerance was not observed when treatment was stopped, and no higher proportion of cells with a T regulatory phenotype (e.g. CD4(+)CD25(+)) were induced. The mechanism appears to involve modulating a proinflammatory cytokine, as the proportion of pancreatic-infiltrating IFN-gamma-positive cells was significantly reduced in the mAb I-10-treated group. These results demonstrate an unexpected role for pm-LAMP-1 in autoimmune disease progression, and suggest that further investigation should be performed to understand how this molecule modulates IFN-gamma-driven responses. |
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Authors:
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Marcelo De Carvalho Bittencourt; Suzanne Herren; Pierre Graber; Francis Vilbois; Christian Pasquali; Claude Berney; Thomas Plitz; Ferdinando Nicoletti; Marie H Kosco-Vilbois |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of immunology Volume: 35 ISSN: 0014-2980 ISO Abbreviation: Eur. J. Immunol. Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-05-02 Completed Date: 2005-06-28 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: Germany |
Other Details:
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Languages: eng Pagination: 1501-9 Citation Subset: IM |
Affiliation:
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Serono Pharmaceutical Research Institute, Geneva, Switzerland. marcelo.decarvalho@chu-fortefrance.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Antibodies, Blocking / immunology*, pharmacology Antibodies, Monoclonal / immunology*, pharmacology Antigens, CD / immunology* Blotting, Western Diabetes Mellitus, Type 1 / immunology*, prevention & control Disease Models, Animal Electrophoresis, Polyacrylamide Gel Female Flow Cytometry Interferon-gamma / biosynthesis, drug effects, immunology Lysosome-Associated Membrane Glycoproteins Membrane Proteins / drug effects, immunology* Mice Mice, Inbred NOD Molecular Sequence Data Pancreas / drug effects, immunology Th1 Cells / drug effects, immunology |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Blocking; 0/Antibodies, Monoclonal; 0/Antigens, CD; 0/Lysosome-Associated Membrane Glycoproteins; 0/Membrane Proteins; 82115-62-6/Interferon-gamma |
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