Document Detail


Extracellular glutamine to glutamate ratio may predict outcome in the injured brain: a clinical microdialysis study in children.
MedLine Citation:
PMID:  12770522     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The amino acid content of hourly microdialysis samples from nine severely head-injured children was examined. Of particular interest was the measurement of the excitatory amino acid glutamate, as high levels of this substance, which are associated with the excitotoxicity cascade, have been linked to high intracranial pressure and poor outcome in a similar study in adults. Interpretation of these data is complicated by many clinical and methodological factors and these are discussed in relation to the findings. Our findings from this pilot study in children confirm the associations between glutamate levels, intracranial pressure and outcome, but fail to corroborate the correlation between excitatory and structural amino acid levels seen in adult patients, that was interpreted as evidence of non-specific leakage of amino acids through damaged cell membranes. In addition, we have shown that the role of glutamine in glutamate homeostasis is an important consideration and that estimation of the extracellular glutamine/glutamate ratio may have some prognostic value in head trauma cases as there is evidence of links to clinical outcome.
Authors:
Douglas A Richards; Christos M Tolias; Spyros Sgouros; Norman G Bowery
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacological research : the official journal of the Italian Pharmacological Society     Volume:  48     ISSN:  1043-6618     ISO Abbreviation:  Pharmacol. Res.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-05-28     Completed Date:  2004-07-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8907422     Medline TA:  Pharmacol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  101-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Medical School, University of Birmingham, Birmingham B15 2TT, UK. d.a.richards@bham.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Amino Acids / metabolism
Brain Injuries / metabolism*
Child
Extracellular Fluid / metabolism*
Female
Glutamic Acid / metabolism*
Glutamine / metabolism*
Humans
Intracranial Pressure / physiology
Male
Microdialysis / methods
Pilot Projects
Prognosis
Chemical
Reg. No./Substance:
0/Amino Acids; 56-85-9/Glutamine; 56-86-0/Glutamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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