| Extracellular glutamine to glutamate ratio may predict outcome in the injured brain: a clinical microdialysis study in children. | |
| | |
MedLine Citation:
|
PMID: 12770522 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The amino acid content of hourly microdialysis samples from nine severely head-injured children was examined. Of particular interest was the measurement of the excitatory amino acid glutamate, as high levels of this substance, which are associated with the excitotoxicity cascade, have been linked to high intracranial pressure and poor outcome in a similar study in adults. Interpretation of these data is complicated by many clinical and methodological factors and these are discussed in relation to the findings. Our findings from this pilot study in children confirm the associations between glutamate levels, intracranial pressure and outcome, but fail to corroborate the correlation between excitatory and structural amino acid levels seen in adult patients, that was interpreted as evidence of non-specific leakage of amino acids through damaged cell membranes. In addition, we have shown that the role of glutamine in glutamate homeostasis is an important consideration and that estimation of the extracellular glutamine/glutamate ratio may have some prognostic value in head trauma cases as there is evidence of links to clinical outcome. |
| | |
Authors:
|
Douglas A Richards; Christos M Tolias; Spyros Sgouros; Norman G Bowery |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Pharmacological research : the official journal of the Italian Pharmacological Society Volume: 48 ISSN: 1043-6618 ISO Abbreviation: Pharmacol. Res. Publication Date: 2003 Jul |
Date Detail:
|
Created Date: 2003-05-28 Completed Date: 2004-07-09 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8907422 Medline TA: Pharmacol Res Country: England |
Other Details:
|
Languages: eng Pagination: 101-9 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, Medical School, University of Birmingham, Birmingham B15 2TT, UK. d.a.richards@bham.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Amino Acids / metabolism Brain Injuries / metabolism* Child Extracellular Fluid / metabolism* Female Glutamic Acid / metabolism* Glutamine / metabolism* Humans Intracranial Pressure / physiology Male Microdialysis / methods Pilot Projects Prognosis |
| Chemical | |
Reg. No./Substance:
|
0/Amino Acids; 56-85-9/Glutamine; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cytoprotective effects of chalcones from Zuccagnia punctata and melatonin on the gastroduodenal trac...
Next Document: Effect of trichostatin a and 5'-azacytidine on transgene reactivation in U937 transduced cells.