Document Detail

Extracellular dopamine and serotonin in the rat striatum during transient ischaemia of different severities: a microdialysis study.
MedLine Citation:
PMID:  8417136     Owner:  NLM     Status:  MEDLINE    
Generalised neurotransmitter overflow into the extracellular space on cerebral ischaemia has been widely reported and implicated in events leading to subsequent neuronal death. As little is known about the effect of depth of ischaemia on these changes, we have subjected anaesthetised rats to a sequence of four challenges [high K+ stimulus, moderate (penumbral) ischaemia, severe ischaemia, cardiac arrest] and have concurrently monitored both electrophysiological parameters and changes in extracellular dopamine, serotonin, and their metabolites in the striatum. Of particular relevance to human stroke therapy was penumbral ischaemia, where ionic homeostasis was maintained even though electrical function was lost. All challenges increased extracellular monoamines, although levels were significantly greater when ischaemia was severe enough to produce sustained anoxic depolarisation. Baseline levels were rapidly restored during recovery phases. Acidic monoamine metabolites decreased significantly during each insult, returning to basal levels during reperfusion after moderate ischaemia, and to significantly higher levels after severe ischaemia. Results indicate that sustained anoxic depolarisation may be a critical factor in determining outcome after ischaemia, being associated with significantly greater release of monoamines, and impairment of electrical function recovery.
D A Richards; T P Obrenovitch; L Symon; G Curzon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  60     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-01-25     Completed Date:  1993-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  128-36     Citation Subset:  IM    
Department of Neurochemistry, Institute of Neurology, London, England.
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MeSH Terms
Corpus Striatum / metabolism*
Dialysis / methods
Dopamine / analogs & derivatives,  metabolism*
Extracellular Space / metabolism*
Ischemic Attack, Transient / metabolism*,  physiopathology
Potassium / pharmacology
Rats, Sprague-Dawley
Serotonin / metabolism*
Reg. No./Substance:
50-67-9/Serotonin; 554-52-9/3-methoxytyramine; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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