| Extracellular changes of taurine in the peri-infarct zone: effect of lubeluzole. | |
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MedLine Citation:
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PMID: 9416317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lubeluzole is a neuroprotective compound that has been shown to stereoselectively rescue sensorimotor function and reduce infarct size in a photochemical stroke model in rats. Tissue swelling, which occurs in the peri-infarct zone, is accompanied by a compensatory taurine release. Therefore, using a microdialysis technique, we aimed at measuring changes of extracellular concentrations of taurine in the peri-infarct zone and the effects of lubeluzole and its R-isomer. Lubeluzole blocked the increase of taurine in tissue immediately surrounding a photochemically induced thrombotic neocortical infarct. By contrast, the R-isomer was completely inactive. We hypothesize that lubeluzole may reduce osmoregulatory stress in peri-infarct tissue. |
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Authors:
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D Scheller; M de Ryck; G Clincke; F Tegtmeier |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta neurochirurgica. Supplement Volume: 70 ISSN: 0065-1419 ISO Abbreviation: Acta Neurochir. Suppl. Publication Date: 1997 |
Date Detail:
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Created Date: 1998-02-26 Completed Date: 1998-02-26 Revised Date: 2004-11-12 |
Medline Journal Info:
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Nlm Unique ID: 100962752 Medline TA: Acta Neurochir Suppl Country: AUSTRIA |
Other Details:
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Languages: eng Pagination: 185-7 Citation Subset: IM |
Affiliation:
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Janseen-Cilag GmbH, Drug Discovery, Neuss, Federal Republic of Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cerebral Infarction / drug therapy*, metabolism Male Neuroprotective Agents / therapeutic use* Piperidines / therapeutic use* Rats Rats, Wistar Stereoisomerism Taurine / metabolism* Thiazoles / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Neuroprotective Agents; 0/Piperidines; 0/Thiazoles; 107-35-7/Taurine; 144665-07-6/lubeluzole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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