| Extracellular acidosis protects Ehrlich ascites tumor cells and rat renal cortex against anoxic injury. | |
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MedLine Citation:
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PMID: 4858002 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study indicates that extracellular acidosis protects Ehrlich ascites tumor cells and rat kidney cortex cells against injury from anoxia. Parameters measured included cell potassium, adenosine 5'-triphosphate, and uptake of vital dyes. Cells survived longer at a pH of 5.6 to 6.5 than at a pH of 7.4; pH 7.9 was most detrimental. These findings indicate that production of protons by anoxic cells may be a protective feedback mechanism. |
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Authors:
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A Penttila; B F Trump |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 185 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1974 Jul |
Date Detail:
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Created Date: 1974-08-22 Completed Date: 1974-08-22 Revised Date: 2011-12-27 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 277-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anaerobiosis Animals Carcinoma, Ehrlich Tumor Cell Line Cell Survival Cells, Cultured* Hydrogen-Ion Concentration* Kidney Cortex / cytology, metabolism Oxygen* Potassium / metabolism Time Factors |
| Chemical | |
Reg. No./Substance:
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7440-09-7/Potassium; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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