Document Detail

Extracellular acidosis protects Ehrlich ascites tumor cells and rat renal cortex against anoxic injury.
MedLine Citation:
PMID:  4858002     Owner:  NLM     Status:  MEDLINE    
The present study indicates that extracellular acidosis protects Ehrlich ascites tumor cells and rat kidney cortex cells against injury from anoxia. Parameters measured included cell potassium, adenosine 5'-triphosphate, and uptake of vital dyes. Cells survived longer at a pH of 5.6 to 6.5 than at a pH of 7.4; pH 7.9 was most detrimental. These findings indicate that production of protons by anoxic cells may be a protective feedback mechanism.
A Penttila; B F Trump
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  185     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1974 Jul 
Date Detail:
Created Date:  1974-08-22     Completed Date:  1974-08-22     Revised Date:  2011-12-27    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  277-8     Citation Subset:  IM    
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MeSH Terms
Carcinoma, Ehrlich Tumor
Cell Line
Cell Survival
Cells, Cultured*
Hydrogen-Ion Concentration*
Kidney Cortex / cytology,  metabolism
Potassium / metabolism
Time Factors
Reg. No./Substance:
7440-09-7/Potassium; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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