Document Detail


Extracellular matrix proteins in hemostasis and thrombosis.
MedLine Citation:
PMID:  21937733     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The adhesion and aggregation of platelets during hemostasis and thrombosis represents one of the best-understood examples of cell-matrix adhesion. Platelets are exposed to a wide variety of extracellular matrix (ECM) proteins once blood vessels are damaged and basement membranes and interstitial ECM are exposed. Platelet adhesion to these ECM proteins involves ECM receptors familiar in other contexts, such as integrins. The major platelet-specific integrin, αIIbβ3, is the best-understood ECM receptor and exhibits the most tightly regulated switch between inactive and active states. Once activated, αIIbβ3 binds many different ECM proteins, including fibrinogen, its major ligand. In addition to αIIbβ3, there are other integrins expressed at lower levels on platelets and responsible for adhesion to additional ECM proteins. There are also some important nonintegrin ECM receptors, GPIb-V-IX and GPVI, which are specific to platelets. These receptors play major roles in platelet adhesion and in the activation of the integrins and of other platelet responses, such as cytoskeletal organization and exocytosis of additional ECM ligands and autoactivators of the platelets.
Authors:
Wolfgang Bergmeier; Richard O Hynes
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-02-01
Journal Detail:
Title:  Cold Spring Harbor perspectives in biology     Volume:  4     ISSN:  1943-0264     ISO Abbreviation:  Cold Spring Harb Perspect Biol     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-03     Completed Date:  2012-06-12     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  101513680     Medline TA:  Cold Spring Harb Perspect Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Platelets / metabolism*
Extracellular Matrix / metabolism*
Extracellular Matrix Proteins / metabolism*
Humans
Platelet Activation / physiology
Platelet Adhesiveness / physiology
Thrombosis / blood*
Grant Support
ID/Acronym/Agency:
R01 HL094594/HL/NHLBI NIH HHS; R01 HL106009/HL/NHLBI NIH HHS; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
0/Extracellular Matrix Proteins
Comments/Corrections

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