Document Detail

Extracellular matrix and fibroblast communication following myocardial infarction.
MedLine Citation:
PMID:  22926488     Owner:  NLM     Status:  MEDLINE    
The extracellular matrix (ECM) provides structural support by serving as a scaffold for cells, and as such the ECM maintains normal tissue homeostasis and mediates the repair response following injury. In response to myocardial infarction (MI), ECM expression is generally upregulated in the left ventricle (LV), which regulates LV remodeling by modulating scar formation. The ECM directly affects scar formation by regulating growth factor release and cell adhesion and indirectly affects scar formation by regulating the inflammatory, angiogenic, and fibroblast responses. This review summarizes the current literature on ECM expression patterns and fibroblast mechanisms in the myocardium, focusing on the ECM response to MI. In addition, we discuss future research areas that are needed to better understand the molecular mechanisms of ECM action, both in general and as a means to optimize infarct healing.
Yonggang Ma; Ganesh V Halade; Merry L Lindsey
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2012-08-28
Journal Detail:
Title:  Journal of cardiovascular translational research     Volume:  5     ISSN:  1937-5395     ISO Abbreviation:  J Cardiovasc Transl Res     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-05-21     Revised Date:  2014-06-11    
Medline Journal Info:
Nlm Unique ID:  101468585     Medline TA:  J Cardiovasc Transl Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  848-57     Citation Subset:  IM    
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MeSH Terms
CCN Intercellular Signaling Proteins / metabolism
Cell-Matrix Junctions / metabolism*,  pathology
Cicatrix / metabolism,  pathology
Extracellular Matrix / metabolism*,  pathology
Fibroblasts / metabolism*,  pathology
Myocardial Infarction / metabolism*,  pathology
Myocardium / metabolism*,  pathology
Signal Transduction*
Grant Support
1K99AT006704-01/AT/NCCAM NIH HHS; HHSN268201000036C/HL/NHLBI NIH HHS; HHSN268201000036C (N01-HV-00244)/HV/NHLBI NIH HHS; K99 AT006704/AT/NCCAM NIH HHS; R00 AT006704/AT/NCCAM NIH HHS; R01 HL075360/HL/NHLBI NIH HHS; R01 HL075360/HL/NHLBI NIH HHS
Reg. No./Substance:
0/CCN Intercellular Signaling Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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