Document Detail


Extracellular matrix degradation and remodeling in development and disease.
MedLine Citation:
PMID:  21917992     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The extracellular matrix (ECM) serves diverse functions and is a major component of the cellular microenvironment. The ECM is a highly dynamic structure, constantly undergoing a remodeling process where ECM components are deposited, degraded, or otherwise modified. ECM dynamics are indispensible during restructuring of tissue architecture. ECM remodeling is an important mechanism whereby cell differentiation can be regulated, including processes such as the establishment and maintenance of stem cell niches, branching morphogenesis, angiogenesis, bone remodeling, and wound repair. In contrast, abnormal ECM dynamics lead to deregulated cell proliferation and invasion, failure of cell death, and loss of cell differentiation, resulting in congenital defects and pathological processes including tissue fibrosis and cancer. Understanding the mechanisms of ECM remodeling and its regulation, therefore, is essential for developing new therapeutic interventions for diseases and novel strategies for tissue engineering and regenerative medicine.
Authors:
Pengfei Lu; Ken Takai; Valerie M Weaver; Zena Werb
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-12-01
Journal Detail:
Title:  Cold Spring Harbor perspectives in biology     Volume:  3     ISSN:  1943-0264     ISO Abbreviation:  Cold Spring Harb Perspect Biol     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-02     Completed Date:  2012-06-04     Revised Date:  2014-01-08    
Medline Journal Info:
Nlm Unique ID:  101513680     Medline TA:  Cold Spring Harb Perspect Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Patterning
Cell Differentiation
Extracellular Matrix / metabolism*,  ultrastructure
Extracellular Matrix Proteins / metabolism*
Mice
Models, Biological
Neoplasms / metabolism,  ultrastructure
Peptide Hydrolases / metabolism,  physiology
Signal Transduction
Stem Cells / cytology
Vertebrates / growth & development,  metabolism
Grant Support
ID/Acronym/Agency:
R01 CA057621/CA/NCI NIH HHS; R01 CA057621/CA/NCI NIH HHS; R01 CA138818/CA/NCI NIH HHS; R01 CA138818/CA/NCI NIH HHS; R03 HD060807/HD/NICHD NIH HHS; U01 ES019458/ES/NIEHS NIH HHS; U01 ES019458/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Extracellular Matrix Proteins; EC 3.4.-/Peptide Hydrolases
Comments/Corrections

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