Document Detail

Extracellular K+ and H+ shifts in early ischemia: mechanisms and relation to changes in impulse propagation.
MedLine Citation:
PMID:  2448490     Owner:  NLM     Status:  MEDLINE    
Heart and skeletal muscle cells rapidly lose potassium ions after withdrawal of oxygen. In myocardial ischemia, cellular release of potassium and interruption of extracellular washout produce a rapid and marked increase of extracellular K+ concentration. Harris et al. were the first to observe the coincidence of the K+ shift and the frequent occurrence of ventricular arrhythmias. They ascribed a major role to K+ in the genesis of the electrophysiological changes in early ischemia. The purpose of this article is to outline briefly in the first part the relationship between potassium accumulation and the electrical changes in ischemia with emphasis on reviewing the role of K+ in the slowing of impulse propagation and production of conduction block. In the second part, the possible mechanisms leading to potassium imbalance will be discussed and experimental data will be presented which suggest that an important component of net potassium loss is related to the development of acidosis.
A G Kléber; C B Riegger; M J Janse
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  19 Suppl 5     ISSN:  0022-2828     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1988-03-15     Completed Date:  1988-03-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  35-44     Citation Subset:  IM    
Dept. of Physiology, University of Berne, Switzerland.
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MeSH Terms
Acidosis / metabolism
Coronary Disease / metabolism*,  physiopathology
Extracellular Space / metabolism
Guinea Pigs
Heart Conduction System / physiopathology*
Hydrogen-Ion Concentration
Ion Channels / metabolism*
Myocardium / metabolism*
Potassium / metabolism*
Reg. No./Substance:
0/Ion Channels; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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