Document Detail

Extracapsular invasion as a risk factor for disease recurrence in colorectal cancer.
MedLine Citation:
PMID:  21528079     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate the presence of extracapsular invasion (ECI) in positive nodes as a predictor of disease recurrence disease in colorectal cancer.
METHODS: Two hundred and twenty-eight consecutive patients who underwent colorectal resection were identified for inclusion in this study, of which 46 had positive lymph nodes. Among 46 cases with stage IIIcolorectal cancer, 16 had ECI at positive nodes and 8 had disease recurrence. The clinical and pathological features of these cases were reviewed.
RESULTS: In the univariate analysis, the number of positive lymph nodes and depth of tumor invasion were significantly associated with the presence of ECI at positive nodes. Multivariate analysis demonstrated that only ECI was a predictor of recurrence. The recurrence-free interval differed significantly among patients with ECI at positive nodes.
CONCLUSION: Our results suggest that ECI at metastatic nodes can identify which cases are at high risk of short-term disease recurrence in colorectal cancer.
Takaaki Fujii; Yuichi Tabe; Reina Yajima; Satoru Yamaguchi; Soichi Tsutsumi; Takayuki Asao; Hiroyuki Kuwano
Related Documents :
3773069 - Remarkable responses of metastatic renal cell cancer in multiple organs treated with al...
21552209 - Loss of e-cadherin expression and outcome among patients with resectable pancreatic ade...
2987429 - Phase i clinical trial of intralesional or intraventricular leukocyte interferon for in...
10022219 - Weekly systemic combination of cisplatin and interferon alpha 2a in diffuse malignant p...
21495929 - Salvage therapy for relapsed chronic lymphocytic leukemia.
2259919 - Treatment of low-grade non-hodgkin's lymphoma by cytoreductive chemotherapy with predni...
21404199 - Laparoscopic retroperitoneal lymph node dissection for stage i nonseminomatous germ cel...
20062719 - Extensive arterial and venous thrombo-embolism with chemotherapy for testicular cancer:...
23253379 - Combined analysis of intratumoral human equilibrative nucleoside transporter 1 (hent1) ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  17     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-29     Completed Date:  2011-08-11     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  2003-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Colorectal Neoplasms / pathology*,  prevention & control*,  surgery
Disease-Free Survival
Lymph Nodes / pathology
Lymphatic Metastasis / pathology*
Middle Aged
Multivariate Analysis
Neoplasm Staging
Retrospective Studies
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Microscopic colitis as a missed cause of chronic diarrhea.
Next Document:  Impact of disease severity on gastric residual volume in critical patients.