| Extra-weak chemiluminescence of drugs. VIII. Extra-weak chemiluminescence arising from the amino-carbonyl reaction. | |
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MedLine Citation:
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PMID: 2540627 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extra-weak chemiluminescence (CL) from amino-carbonyl reactions of L-lysine with various sugars and aldehydes in aqueous solution was examined. Amongst the aldehydes and sugars tested, glycoaldehyde and D-arabinose produced the highest CL intensity. The CL of the amino-carbonyl reaction reached a maximum after about 60 minutes. The CL was pH dependent, and a linear relation between CL intensity and hydrogen-ion concentration was demonstrated. Low oxygen levels inhibited CL and no CL was produced in nitrogen purged solutions. Addition of cupric or ferrous ion, decreased the CL. The involvement of free radical intermediates was demonstrated by ESR. Our findings suggest that the CL of the amino-carbonyl reaction arises from free radicals derived from melanoidines or their intermediates. CL should prove useful for evaluating the stability of crude drugs extracted from natural resources that contain various amino acid derivatives protein and sugar components. |
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Authors:
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Y Kurosaki; H Sato; M Mizugaki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of bioluminescence and chemiluminescence Volume: 3 ISSN: 0884-3996 ISO Abbreviation: J. Biolumin. Chemilumin. Publication Date: 1989 Jan-Mar |
Date Detail:
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Created Date: 1989-05-26 Completed Date: 1989-05-26 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8612490 Medline TA: J Biolumin Chemilumin Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 13-9 Citation Subset: IM |
Affiliation:
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Pharmaceutical Sciences, Tohoku University Hospital, Miyagi, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldehydes* Cations, Divalent Chemical Phenomena Chemistry Electron Spin Resonance Spectroscopy Hydrogen-Ion Concentration Ketones* Kinetics Luminescent Measurements* |
| Chemical | |
Reg. No./Substance:
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0/Aldehydes; 0/Cations, Divalent; 0/Ketones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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