| Extra-uterine myoid tumours in patients with acquired immunodeficiency syndrome: a clinicopathological reappraisal. | |
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MedLine Citation:
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PMID: 22175892 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Ramdial P K, Sing Y, Deonarain J, Vaubell J I, Naicker S, Sydney C, Hadley L G P, Singh B, Kiratu E, Gundry B & Sewram V (2011) Histopathology 59, 1122-1134 Extra-uterine myoid tumours in patients with acquired immunodeficiency syndrome: a clinicopathological reappraisal Aims: AIDS-associated myoid tumours (AIDS-MTs), often Epstein-Barr virus (EBV)-associated (EBV-positive MTs), include smooth muscle tumors (SMTs) and the relatively recently recognized myopericytomas (MPCTs). The myoid immunophenotype of AIDS-MTs has been documented inconsistently. The aim of this study was to reappraise the phenotypic and immunophenotypic features of extra-uterine AIDS-MTs and the clinical profile of afflicted patients. Methods and results: EBV early RNA in-situ hybridization testing on 27 AIDS-MTs from 25 patients identified 19 of 27 (70.4%) EBV-positive MTs and eight of 27 (29.6%) EBV-negative MTs. EBV-positive MTs comprised 12 of 19 EBV-positive SMTs [six leiomyomas, one smooth muscle tumour of uncertain malignant potential (STUMP), five leiomyosarcomas] and seven of 19 EBV-positive MPCTs [benign (five), malignant (two)]. The EBV-negative MTs, made up exclusively of EBV-negative SMTs, included angioleiomyoma (one), leiomyoma (one), STUMP (one) and leiomyosarcomas (five). Malignant AIDS-MTs demonstrated hypercellularity, pleomorphism, increased mitoses and necrosis. EBV-positive leiomyosarcomas retained a conspicuous fascicular architecture. Four of five EBV-negative leiomyosarcomas demonstrated marked pleomorphism. All EBV-positive MPCTs and two EBV-positive leiomyosarcomas contained aggregates of desmin-negative round and oval cells. Seventeen of 25 patients died, mainly from comorbid diseases. Conclusion: While the reappraised spectrum of AIDS-MTs does not demonstrate divergent subtype-determined clinical behaviour, heightened awareness/recognition of this expanded spectrum will not only promote improved diagnosis of pleomorphic and myopericytic variants, which may be the sentinel clue to AIDS and its comorbidity, but will also facilitate distinction from histopathological mimics in specific anatomic locations. |
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Authors:
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Pratistadevi K Ramdial; Yetish Sing; Julian Deonarain; Jalaludin I Vaubell; Shaun Naicker; Clive Sydney; Larry G P Hadley; Bhugwan Singh; Erastus Kiratu; Brian Gundry; Vikash Sewram |
Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Histopathology Volume: 59 ISSN: 1365-2559 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7704136 Medline TA: Histopathology Country: - |
Other Details:
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Languages: ENG Pagination: 1122-1134 Citation Subset: - |
Copyright Information:
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© 2011 Blackwell Publishing Limited. |
Affiliation:
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Department of Anatomical Pathology, University of KwaZulu Natal Nelson R Mandela School of Medicine, University of KwaZulu Natal National Health Laboratory Service, South African Medical Research Council, Durban, KwaZulu Natal Department of Paediatric Surgery, University of KwaZulu Natal Department of General Surgery, University of KwaZulu Natal Department of Neurosurgery, University of KwaZulu Natal Department of Ophthalmology, University of KwaZulu Natal Oncology Research Unit, South African Medical Research Council, Durban, KwaZulu Natal, South Africa. |
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