Document Detail

Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence.
MedLine Citation:
PMID:  20639519     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common metabolic dysfunction and heterogeneous endocrine disorder in women of reproductive age. Although patients with PCOS are typically characterized by increased numbers of oocytes retrieved during IVF, they are often of poor quality, leading to lower fertilization, cleavage and implantation rates, and a higher miscarriage rate.
METHODS: For this review, we searched the database MEDLINE (1950 to January 2010) and Google for all full texts and/or abstract articles published in English with content related to oocyte maturation and embryo developmental competence.
RESULTS: The search showed that alteration of many factors may directly or indirectly impair the competence of maturating oocytes through endocrine and local paracrine/autocrine actions, resulting in a lower pregnancy rate in patients with PCOS. The extra-ovarian factors identified included gonadotrophins, hyperandrogenemia and hyperinsulinemia, although intra-ovarian factors included members of the epidermal, fibroblast, insulin-like and neurotrophin families of growth factors, as well as the cytokines.
CONCLUSIONS: Any abnormality in the extra- and/or intra-ovarian factors may negatively affect the granulosa cell-oocyte interaction, oocyte maturation and potential embryonic developmental competence, contributing to unsuccessful outcomes for patients with PCOS who are undergoing assisted reproduction.
Jie Qiao; Huai L Feng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-07-16
Journal Detail:
Title:  Human reproduction update     Volume:  17     ISSN:  1460-2369     ISO Abbreviation:  Hum. Reprod. Update     Publication Date:    2011 Jan-Feb
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-04-08     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9507614     Medline TA:  Hum Reprod Update     Country:  England    
Other Details:
Languages:  eng     Pagination:  17-33     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100083, People's Republic of China.
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MeSH Terms
Embryonic Development*
Follicle Stimulating Hormone / deficiency
Hyperandrogenism / complications
Hyperinsulinism / complications
Intercellular Signaling Peptides and Proteins / physiology
Luteinizing Hormone / secretion
Oocytes / growth & development*,  metabolism
Ovary / physiopathology*
Paracrine Communication
Polycystic Ovary Syndrome / complications,  embryology*,  metabolism
Reg. No./Substance:
0/Intercellular Signaling Peptides and Proteins; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

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