Document Detail

Extra-esophageal manifestations of gastroesophageal reflux.
MedLine Citation:
PMID:  17577320     Owner:  NLM     Status:  MEDLINE    
Gastroesophageal reflux disease (GERD) is a common medical condition affecting approximately 35-40% of the adult population in the western world. The role of GERD in causing extra-esophageal symptoms including laryngitis, asthma, cough, chest pain, and dental erosions is increasingly recognized with renewed interest among gastroenterologists and other specialists. Direct injury by mucosal contact, and vagally mediated reflex from distal esophageal acid exposure are the two possible mechanisms by which reflux-related extra-esophageal tissue injuries may occur. Several investigational techniques may be used to diagnose gastroesophageal reflux; however, because of the poor sensitivity of endoscopy and pH monitoring, and the poor specificity of laryngoscopy, empiric therapy with proton-pump inhibitors (PPI) is now considered the initial diagnostic step in patients suspected of having GERD-related symptoms. In those who improve with such therapy, it is likely that GERD may be the cause of the extra-esophageal presentation. In those who are unresponsive to such therapy, other diagnostic testing such as impedance/pH monitoring may be reasonable in order to exclude continued acid or weakly acid reflux. However, PPI-unresponsive patients usually have causes other than GERD for the extra-esophageal symptoms and signs.
F Farrokhi; M F Vaezi
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Oral diseases     Volume:  13     ISSN:  1354-523X     ISO Abbreviation:  Oral Dis     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-19     Completed Date:  2007-08-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508565     Medline TA:  Oral Dis     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  349-59     Citation Subset:  D    
Division of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Asthma / etiology
Cough / etiology
Gastroesophageal Reflux / complications*,  diagnosis,  drug therapy
Laryngitis / etiology
Mouth Diseases / etiology*
Respiratory Tract Diseases / etiology*
Sinusitis / etiology
Tooth Diseases / etiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Protease-activated receptor 1-selective antagonist SCH79797 inhibits cell proliferation and induces ...
Next Document:  Oral and maxillofacial manifestations of familial adenomatous polyposis.