Document Detail

Extra copy of 20q deletion, acute myelomonocytic leukemia (M4) and Niemann-Pick disease.
MedLine Citation:
PMID:  16027483     Owner:  NLM     Status:  PubMed-not-MEDLINE    
A 59-year-old hypertensive white male was diagnosed with acute myelogenous leukemia (AML), M4. A bone marrow aspirate showed a karyotype of 46,XY,del(20)(q11.2q13.3)[12]/ 47,XY,del(20)(q11.2q13.3)x2[8]. The majority of cases with 20q deletion are associated with myeloid disorders; however, an extra copy of the 20q deletion has rarely been reported. The patient expired seven days after admission to the hospital. At autopsy hepatosplenomegaly was present. Many foamy macrophages with bubbling cytoplasm in the spleen, liver, bone marrow and lymph nodes were suggestive of Niemann-Pick disease, type E. AML has not previously been reported with Niemann-Pick disease.
Dana M Wonsettler; William W L Chang; Sharon L Wenger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Association of Genetic Technologists     Volume:  31     ISSN:  1523-7834     ISO Abbreviation:  J Assoc Genet Technol     Publication Date:  2005  
Date Detail:
Created Date:  2005-07-19     Completed Date:  2005-10-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9807282     Medline TA:  J Assoc Genet Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  55-8     Citation Subset:  -    
Department of Pathology, West Virginia University, P. O. Box 9203, Morgantown, WV 26506-9203, USA.
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