| Extra-anogenital bilharziasis cutanea tarda revisited. | |
| | |
MedLine Citation:
|
PMID: 19519608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Even in schistosomiasis-endemic areas, extra-anogenital bilharziasis cutanea tarda (E-BCT) is rare. To date, the occurrence of E-BCT in pre-existing cutaneous pathology is undocumented. The study was undertaken to document the expanded clinicopathological spectrum and to comment on the putative pathogenetic mechanisms of a Schistosoma hematobium-associated E-BCT. METHODS: Eight-year clinicopathological appraisal of E-BCT. RESULTS: The clinical details are as follows. Seventeen specimens from 16 patients formed the study cohort. All specimens showed granulomatous inflammation with eosinophils, aggregates of terminal-spined S. hematobium ova and variable fibrosis. Copulating worms were identified in three biopsies. In 12/16 patients, E-BCT occurred in pre-existing pathology, including recurrent squamous papilloma (1), bilateral hidradenitis suppurativa (1) and scar tissue (10) with 7 showing a keloidal morphology. Prior and current urinary schistosomiasis was present in nine and seven patients, respectively. CONCLUSION: E-BCT, a reflection of prior, re-infective or inadequately treated urinary schistosomiasis, is deemed to be a function of egg-laying consequent to the aberrant pathway of worms. Based on E-BCT occurrence in pre-existing extra-anogenital cutaneous fibroinflammatory and cicatricial processes and the presence of adult worms in three extra-anogenital biopsies in the present study, it is hypothesized that altered tissue mesenchymal repair reactions may promote extra-anogenital cutaneous worm entrapment and egg-laying. |
| | |
Authors:
|
Pratistadevi K Ramdial; Eduardo Calonje; Bhugwan Singh; Yetish Sing; Prashni Govender |
Related Documents
:
|
7827598 - Colposcopy in women with a normal papanicolaou smear. 21813588 - Predictors of mortality and end stage renal disease in saudi patients with lupus nephri... 6471338 - Autopsy findings in the acquired immune deficiency syndrome. 458768 - Cervical dysplasia in a large, predominantly black practice as diagnosed by colposcopy ... 17980738 - Oculoleptomeningeal amyloidosis in a patient with a ttr val30gly mutation in the transt... 139958 - The plasma cholinesterase variants in mentally ill patients. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of cutaneous pathology Volume: 36 ISSN: 1600-0560 ISO Abbreviation: J. Cutan. Pathol. Publication Date: 2009 Jul |
Date Detail:
|
Created Date: 2009-06-12 Completed Date: 2009-08-18 Revised Date: 2010-03-24 |
Medline Journal Info:
|
Nlm Unique ID: 0425124 Medline TA: J Cutan Pathol Country: Denmark |
Other Details:
|
Languages: eng Pagination: 766-71 Citation Subset: IM |
Copyright Information:
|
(c) 2009 The Authors. Journal Compilation (c) 2009 Blackwell Munksgaard. |
Affiliation:
|
Department of Anatomical Pathology, Nelson R Mandela School of Medicine, University of KwaZulu Natal, Durban, KwaZulu Natal, South Africa. ramdial@ukzn.ac.za |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Animals Biopsy Cohort Studies Humans Male Middle Aged Schistosoma haematobium* Schistosomiasis / pathology* Skin Diseases, Parasitic / pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Investigation of the effect of UV irradiation on DNA damage: comparison between skin cancer patients...
Next Document: Bitumen products induce skin cell apoptosis in chronically exposed road pavers.