Document Detail

Extra-ampullary Duodenal Adenocarcinoma.
MedLine Citation:
PMID:  25310836     Owner:  NLM     Status:  In-Data-Review    
Extra-ampullary duodenal adenocarcinomas are rare, and when studied, frequently have been grouped with jejunoileal adenocarcinomas. Nevertheless, anecdotal experiences suggest that these neoplasms may present 2 or more distinct phenotypes. To better characterize these neoplasms, we performed a retrospective review of 38 cases with a special focus on the morphologic and immunophenotypic characteristics and their clinicopathologic significance. Our cohort of extra-ampullary duodenal adenocarcinomas was classified on the basis of the morphologic features into gastric type (n=19, 50%), intestinal type (n=14, 37%), pancreaticobiliary type (n=2, 5%), and others (n=3, 8%). Most gastric-type adenocarcinomas (n=18, 95%) developed in the proximal duodenum, whereas the other types were located equally in the proximal and distal duodenum. Intestinal-type dysplasia was present at the periphery of 8 (57%) intestinal-type adenocarcinomas, and 8 (42%) gastric-type adenocarcinoma were associated with gastric-type dysplasia. Gastric foveolar metaplasia (n=12) and Brunner gland hyperplasia (n=10) were exclusively recognized adjacent to gastric-type adenocarcinomas. Notably, intestinal-type histology and the absence of lymph node metastasis were significantly associated with favorable disease-free survival in univariate and multivariate analyses. In summary, this study demonstrated that 2 major subsets of extra-ampullary duodenal adenocarcinoma, intestinal type and gastric type, are associated with distinct histopathologic features and clinical behavior.
Tetsuo Ushiku; Thomas Arnason; Masashi Fukayama; Gregory Y Lauwers
Related Documents :
22017406 - Small renal cell carcinoma: oncological outcome with tumour size.
25210686 - Prognostic implications of primary tumor resection in stage ivb colorectal cancer in el...
18722226 - Prognostic factors of unknown primary head and neck squamous cell carcinoma.
2431756 - Multidrug chemotherapy using bleomycin, methotrexate, and cisplatin combined with radic...
23725896 - Outcome of colorectal cancer resection in octogenarians.
23079156 - A phase ii study of modulated-capecitabine and docetaxel in chemonaive patients with ad...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of surgical pathology     Volume:  38     ISSN:  1532-0979     ISO Abbreviation:  Am. J. Surg. Pathol.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-10-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7707904     Medline TA:  Am J Surg Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1484-93     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  T-cell Prolymphocytic Leukemia Frequently Shows Cutaneous Involvement and Is Associated With Gains o...
Next Document:  Gastric High-grade Dysplasia Can Be Associated With Submucosal Invasion: Evaluation of its Prevalenc...