| Extra-acral cutaneous/soft tissue sclerosing perineurioma: an under-recognized entity in the differential of CD34-positive cutaneous neoplasms. | |
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MedLine Citation:
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PMID: 20412342 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Perineuriomas are an uncommon group of tumors composed of perineurial cells of peripheral nerve sheath lineage. Variants include soft tissue (extraneural), intraneural, sclerosing, reticular and plexiform forms. Sclerosing perineuriomas have been reported to occur almost exclusively on the hands of young men. Herein, we report three extra-acral cutaneous/soft tissue perineuriomas that show significant associated sclerosis. METHODS: Skin biopsy specimens from three patients were evaluated for cytomorphology and degree of associated sclerosis, which was classified as either focal or diffuse. Immunohistochemical expression of epithelial membrane antigen (EMA), CD34 and S-100 was also assessed to facilitate further classification. RESULTS: Histopathologically, the tumors showed both focal and diffuse sclerosis, and lesional cells were generally spindled in shape. Immunohistochemical staining showed diffuse positivity for CD34 and focal or diffuse positivity for EMA. The cells uniformly lacked expression of S-100 protein. CONCLUSIONS: Sclerosing perineuriomas can occur in extra-acral locations and should be considered in the differential of EMA-positive cutaneous spindle-cell proliferations. It is also important to recognize that perineuriomas can express CD34 and should be considered in the differential diagnosis of CD34-positive cutaneous neoplasms. |
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Authors:
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Melanie D Fox; Briana C Gleason; Antoinette B Thomas; Thomas A Victor; Thomas L Cibull |
Publication Detail:
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Type: Journal Article Date: 2010-04-12 |
Journal Detail:
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Title: Journal of cutaneous pathology Volume: 37 ISSN: 1600-0560 ISO Abbreviation: J. Cutan. Pathol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-19 Completed Date: 2010-12-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0425124 Medline TA: J Cutan Pathol Country: Denmark |
Other Details:
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Languages: eng Pagination: 1053-6 Citation Subset: IM |
Affiliation:
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Department of Pathology, Northshore University HealthSystem, Evanston, IL, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged, 80 and over Antigens, CD34 / metabolism Diagnosis, Differential Female Humans Immunohistochemistry Middle Aged Mucin-1 / metabolism Nerve Sheath Neoplasms / metabolism, pathology* Skin Neoplasms / metabolism, pathology* Soft Tissue Neoplasms / metabolism, pathology* Tumor Markers, Biological / analysis |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD34; 0/Mucin-1; 0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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