| Extinction deficits in male rhesus macaques with a history of self-injurious behavior. | |
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MedLine Citation:
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PMID: 15195326 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Self-injurious behavior (SIB) occurs in both human and nonhuman primate populations. Despite the potential for harm, SIB may persist in part because of an inability to inhibit behavior that results in wounding. A lever-pressing task was used to test the prediction that monkeys with SIB would show greater persistence in lever-pressing on extinction trials than monkeys without the disorder. The subjects were 15 individually-housed adult male rhesus macaques, 10 of which (the SIB group) had a veterinary record of self-inflicted wounding. All of the monkeys were trained to lever-press for food rewards to a criterion of 400 total responses. The test procedures consisted of five daily 30-min sessions divided into six 5-min intervals. On day 1, the subjects received continuous reinforcement. On days 2-4, testing consisted of alternating reinforced/unreinforced 5-min intervals, beginning with reinforcement. Reinforced intervals were cued with a buzzer. On day 5, the subjects received no reinforcement. The number of lever-presses and behavioral responses were recorded during each session. Saliva samples were collected for cortisol measurement before and after test sessions on days 1, 2, and 5. As predicted, monkeys with SIB lever-pressed more than controls during extinction intervals on days 2-4. There was no difference on day 1 or day 5. The frequency of scratching, yawning, and abnormal behavior increased when reinforcement was intermittent (days 2-4) or absent (day 5). Cortisol levels were highest with continuous reinforcement (day 1), and may reflect differential levels of food intake rather than stress. The presence of extinction deficits suggests that SIB may persist in some monkeys because they lack the ability to regulate the intensity of their biting behavior. |
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Authors:
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Corrine Lutz; Stefan Tiefenbacher; Jerrold Meyer; Melinda Novak |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of primatology Volume: 63 ISSN: 0275-2565 ISO Abbreviation: Am. J. Primatol. Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-06-14 Completed Date: 2004-08-06 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8108949 Medline TA: Am J Primatol Country: United States |
Other Details:
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Languages: eng Pagination: 41-8 Citation Subset: IM |
Copyright Information:
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Copyright 2004 Wiley-Liss, Inc. |
Affiliation:
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New England Primate Research Center, Southborough, Massachusetts 01772-9102, USA. Corrine_Lutz@hms.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Extinction, Psychological / physiology* Hydrocortisone / metabolism Macaca mulatta / physiology* Male Reinforcement (Psychology) Reward Saliva / chemistry Self-Injurious Behavior* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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RR00168/RR/NCRR NIH HHS; RR11122/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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