Document Detail

Extinction bursts in rats trained to self-administer nicotine or food in 1-h daily sessions.
MedLine Citation:
PMID:  23145210     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Extinction bursts are characterized by a temporary increase in responding when drug access is withheld from rats trained to self-administer drugs of abuse. Thus far, one study has examined extinction bursts for nicotine self-administration using a 23-h access paradigm [1]. Here we examined extinction bursts using previously published and unpublished data in which rats were trained to self-administer nicotine (0.03mg/kg/infusion) or food pellets (as a comparator) in 1-h sessions under an FR5 schedule of reinforcement followed by 1-h extinction sessions. Analysis of response rates during nicotine self-administration (NSA) was indicative of a loading phase, as response rates were significantly higher at the beginning of the session, which was not observed for food self-administration. At the start of extinction for both food and nicotine, although sessional response rates did not increase, there was an increase in response rate during the first 5-min of the first extinction session relative to self-administration. This transient extinction burst following nicotine was observed in a minority of subjects and correlated with the number of nicotine infusions obtained during self-administration. This transient extinction burst following food was observed in all subjects. Nicotine and food produce more transient extinction bursts compared to other drugs of abuse and only for a minority of animals in the case of nicotine. This study supports the presence of a loading phase in rats trained to self-administer nicotine in 1-r daily sessions and the presence of a transient extinction burst.
Abhiram Pushparaj; Yaroslaw Pryslawsky; Benoit Forget; Yijin Yan; Bernard Le Foll
Publication Detail:
Type:  Journal Article     Date:  2012-10-10
Journal Detail:
Title:  American journal of translational research     Volume:  4     ISSN:  1943-8141     ISO Abbreviation:  Am J Transl Res     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-12     Completed Date:  2012-11-27     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101493030     Medline TA:  Am J Transl Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  422-31     Citation Subset:  -    
Translational Addiction Research Laboratory, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health Toronto, Canada.
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