| External incentives and internal states guide goal-directed behavior via the differential recruitment of the nucleus accumbens and the medial prefrontal cortex. | |
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MedLine Citation:
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PMID: 20638448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Goal-directed behavior is governed by internal physiological states and external incentives present in the environment (e.g. hunger and food). While the role of the mesocorticolimbic dopamine (DA) system in behavior guided by environmental incentives has been well studied, the effect of relevant physiological states on the function of this system is less understood. The current study examined the role of the medial prefrontal cortex (mPFC) and the nucleus accumbens (NAcc) in the kind of food-reinforced behaviors known to be sensitive to the internal state produced by food deprivation conditions. Operant lever-press reinforced on fixed ratio 1 (FR1) and progressive ratio (PR) schedules was tested after temporary inactivation of, or DA receptor blockade in, the prelimbic mPFC or NAcc core of rats with differing levels of food deprivation (0, 12 and 36-h). Food deprivation increased PR breakpoints, as well as the number of lever-presses emitted on the FR1 schedule. Both temporary inactivation and DA blockade of NAcc reduced breakpoints across deprivation conditions, while temporary inactivation and DA blockade of mPFC reduced breakpoints only in food-deprived rats. Neither manipulation of mPFC and NAcc had any effect on behavior reinforced on the FR1 schedule. Thus, mPFC and NAcc were differentially relevant to the behaviors tested-NAcc was recruited when the behavioral cost per reinforcer was rising or high regardless of food deprivation conditions, while mPFC was recruited when food-deprived animals behaved through periods of sparse reinforcement density in order to maximize available gain. |
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Authors:
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J M Moscarello; O Ben-Shahar; A Ettenberg |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-07-16 |
Journal Detail:
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Title: Neuroscience Volume: 170 ISSN: 1873-7544 ISO Abbreviation: Neuroscience Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-03 Completed Date: 2011-01-20 Revised Date: 2011-10-13 |
Medline Journal Info:
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Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: United States |
Other Details:
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Languages: eng Pagination: 468-77 Citation Subset: IM |
Copyright Information:
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Copyright 2010 IBRO. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Behavioral Pharmacology Laboratory, Department of Psychology, University of California, Santa Barbara, CA 93106-9660, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Baclofen / administration & dosage, pharmacology Conditioning, Operant / drug effects, physiology* Dopamine Antagonists / administration & dosage, pharmacology Drug Combinations Flupenthixol / administration & dosage, pharmacology Food Deprivation / physiology* GABA-A Receptor Agonists / administration & dosage, pharmacology GABA-B Receptor Agonists / administration & dosage, pharmacology Male Microinjections Motivation / drug effects* Muscimol / administration & dosage, pharmacology Nucleus Accumbens / drug effects, physiology* Prefrontal Cortex / drug effects, physiology* Rats Rats, Sprague-Dawley Reinforcement Schedule |
| Grant Support | |
ID/Acronym/Agency:
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F31-DA024505/DA/NIDA NIH HHS; R01 DA005041-22/DA/NIDA NIH HHS; R01-DA05041/DA/NIDA NIH HHS; R56 DA005041-20/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Antagonists; 0/Drug Combinations; 0/GABA-A Receptor Agonists; 0/GABA-B Receptor Agonists; 1134-47-0/Baclofen; 2709-56-0/Flupenthixol; 2763-96-4/Muscimol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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