Document Detail


External incentives and internal states guide goal-directed behavior via the differential recruitment of the nucleus accumbens and the medial prefrontal cortex.
MedLine Citation:
PMID:  20638448     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Goal-directed behavior is governed by internal physiological states and external incentives present in the environment (e.g. hunger and food). While the role of the mesocorticolimbic dopamine (DA) system in behavior guided by environmental incentives has been well studied, the effect of relevant physiological states on the function of this system is less understood. The current study examined the role of the medial prefrontal cortex (mPFC) and the nucleus accumbens (NAcc) in the kind of food-reinforced behaviors known to be sensitive to the internal state produced by food deprivation conditions. Operant lever-press reinforced on fixed ratio 1 (FR1) and progressive ratio (PR) schedules was tested after temporary inactivation of, or DA receptor blockade in, the prelimbic mPFC or NAcc core of rats with differing levels of food deprivation (0, 12 and 36-h). Food deprivation increased PR breakpoints, as well as the number of lever-presses emitted on the FR1 schedule. Both temporary inactivation and DA blockade of NAcc reduced breakpoints across deprivation conditions, while temporary inactivation and DA blockade of mPFC reduced breakpoints only in food-deprived rats. Neither manipulation of mPFC and NAcc had any effect on behavior reinforced on the FR1 schedule. Thus, mPFC and NAcc were differentially relevant to the behaviors tested-NAcc was recruited when the behavioral cost per reinforcer was rising or high regardless of food deprivation conditions, while mPFC was recruited when food-deprived animals behaved through periods of sparse reinforcement density in order to maximize available gain.
Authors:
J M Moscarello; O Ben-Shahar; A Ettenberg
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-07-16
Journal Detail:
Title:  Neuroscience     Volume:  170     ISSN:  1873-7544     ISO Abbreviation:  Neuroscience     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-03     Completed Date:  2011-01-20     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  468-77     Citation Subset:  IM    
Copyright Information:
Copyright 2010 IBRO. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Baclofen / administration & dosage,  pharmacology
Conditioning, Operant / drug effects,  physiology*
Dopamine Antagonists / administration & dosage,  pharmacology
Drug Combinations
Flupenthixol / administration & dosage,  pharmacology
Food Deprivation / physiology*
GABA-A Receptor Agonists / administration & dosage,  pharmacology
GABA-B Receptor Agonists / administration & dosage,  pharmacology
Male
Microinjections
Motivation / drug effects*
Muscimol / administration & dosage,  pharmacology
Nucleus Accumbens / drug effects,  physiology*
Prefrontal Cortex / drug effects,  physiology*
Rats
Rats, Sprague-Dawley
Reinforcement Schedule
Grant Support
ID/Acronym/Agency:
F31-DA024505/DA/NIDA NIH HHS; R01 DA005041/DA/NIDA NIH HHS; R01-DA05041/DA/NIDA NIH HHS; R56 DA005041/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Dopamine Antagonists; 0/Drug Combinations; 0/GABA-A Receptor Agonists; 0/GABA-B Receptor Agonists; 2763-96-4/Muscimol; FA0UYH6QUO/Flupenthixol; H789N3FKE8/Baclofen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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