| External heart deformities in passerine birds exposed to environmental mixtures of polychlorinated biphenyls during development. | |
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MedLine Citation:
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PMID: 16519318 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Necropsy-observable cardiac deformities were evaluated from 283 nestling passerines collected from one reference site and five polychlorinated biphenyl (PCB)-contaminated sites around Bloomington and Bedford, Indiana, USA. Hearts were weighed and assessed on relative scales in three dimensions (height, length, and width) and for externally visible deformities. Heart weights normalized to body weight (heart somatic index) were decreased significantly at the more contaminated sites in both house wren (Troglodytes aedon) and tree swallow (Tachycineta bicolor). Heart somatic indices significantly correlated with log PCB concentrations in Carolina chickadee (Parus carolinesis) and tree swallow and with log 2,3,7,8-tetrachlorodibenzo-p-dioxin toxic equivalent values in tree swallow alone. Ventricular length was increased significantly in eastern bluebirds (Sialia sialis) and decreased significantly in Carolina chickadee and tree swallow from contaminated sites versus the reference site. Heart length regressed significantly against the log PCB concentrations (Carolina chickadee and tree swallow) or the square of the PCB concentrations (red-winged blackbird [Agelaius phoeniceus]) in a sibling bird. The deformities that were observed most at the contaminated sites included abnormal tips (pointed, rounded, or flattened), center rolls, macro- and microsurface roughness, ventricular indentations on the ventral or dorsal surface, lateral ventricular notches, visibly thin ventricular walls, and changes in overall heart shape. A pooled heart deformity index regressed significantly against the logged contaminant concentrations for all species except red-winged blackbird. These results indicate that developmental changes in heart morphometrics and shape abnormalities are quantifiable and may be sensitive and useful indicators of PCB-related developmental impacts across many avian species. |
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Authors:
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Jamie C DeWitt; Deborah S Millsap; Ronnie L Yeager; Steve S Heise; Daniel W Sparks; Diane S Henshel |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Environmental toxicology and chemistry / SETAC Volume: 25 ISSN: 0730-7268 ISO Abbreviation: Environ. Toxicol. Chem. Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-03-07 Completed Date: 2006-06-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8308958 Medline TA: Environ Toxicol Chem Country: United States |
Other Details:
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Languages: eng Pagination: 541-51 Citation Subset: IM |
Affiliation:
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Curriculum in Toxicology, University of North Carolina at Chapel Hill, Campus Box 7270, 256 Rosenau Hall, Chapel Hill, North Carolina 27599, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Body Weight Environmental Exposure Environmental Monitoring Environmental Pollutants / adverse effects* Hazardous Waste Heart / growth & development Heart Defects, Congenital / chemically induced*, veterinary* Passeriformes / abnormalities*, growth & development Polychlorinated Biphenyls / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Environmental Pollutants; 0/Hazardous Waste; 0/Polychlorinated Biphenyls |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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