| External granular cell layer bobbling: a distinct histomorphological feature of the developing human cerebellum. | |
| | |
MedLine Citation:
|
PMID: 22943957 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Introduction: The external granular layer (EGL) of the developing human cerebellum is detectable until an age of ~ 1 year. It has been described as a thin, evenly calibrated layer of germinal cells. We have repeatedly observed a distinct discontinuous bobbled configuration of the EGL (external granular layer bobbling = EGLB) in human infantile autopsy brains. Aim, materials and methods: We investigated 106 human fetal and infantile postmortem brains (range of gestational week at birth: 14 - term; range of postpartal age: 0 - 500 days) for presence of EGLB and correlated it with gestational/postpartal age, gender, developmental stage of cerebellar cortex, medical history and neuropathological findings. Results: EGLB was detectable in 38/106 (35.8%) cases. EGLB presents as focal series of uniform knob-like protrusions of the EGL. In the notches between individual knobs, capillaries penetrate from the primitive leptomeningeal vascular plexus into the molecular layer. We found EGLB predominantly in depths of fissures of cerebellar hemispheres, vermis and/or tonsils. Presence of EGLB was statistically significantly more common in liveborn cases who died after gestational week 25 and cases with higher maturity grade of the cerebellar cortex, respectively. There was no gender difference. EGLB was not associated with medical history or neuropathological findings. Conclusions: EGLB is a distinct histomorphological feature of the developing cerebellum, which is predominantly found in infants. Our data indicate that EGLB is a physiological phenomenon occuring during cerebellar development at a certain gestational age, although we cannot exclude that it represents an artifact related to tissue fixation. In any case, recognition of this recurring feature is relevant for the practicing neuropathologist and should not be interpreted as a cerebellar migration disorder. |
| | |
Authors:
|
Ellen Gelpi; Herbert Budka; Matthias Preusser |
Related Documents
:
|
15971247 - Marked ascites and serum carbohydrate antigen (ca) 125 elevation in a patient with anor... 23495897 - Sevoflurane alters the expression of receptors and enzymes involved in aβ clearance in... 2599707 - The group as an object in the cultural field. 23015687 - Structural brain alterations associated with schizophrenia preceded by conduct disorder... 9543077 - Changes in sputum composition during sputum induction in healthy and asthmatic subjects. 15611597 - Age-related circadian variations of cardiac and respiratory components of the carotid b... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-9-4 |
Journal Detail:
|
Title: Clinical neuropathology Volume: - ISSN: 0722-5091 ISO Abbreviation: Clin. Neuropathol. Publication Date: 2012 Sep |
Date Detail:
|
Created Date: 2012-9-4 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8214420 Medline TA: Clin Neuropathol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Giant cell glioblastoma with unique bilateral cerebellopontine angle localization considered as extr...
Next Document: Psychiatric disorder co-morbidity and correlates in an ethnically diverse sample of obese patients w...