Document Detail

External detection of regional myocardial metabolism with radioiodinated hexadecenoic acid in the dog heart.
MedLine Citation:
PMID:  7215379     Owner:  NLM     Status:  MEDLINE    
In a previous study we have demonstrated that terminally iodinated hexadecenoic acid (131I-HA) and Thallium-201 (201T1) are comparable in myocardial uptake and distribution in the ischemic dog heart (Westera et al. 1980). In the present study the potential value of 131I-HA was proved in determining regional myocardial metabolism in 19 dog experiments. In ten dogs, 131I-HA was administered 5 min after occlusion of a coronary artery (group II), in six dogs after a 90 min occlusion period (group III). Three dogs served as controls (group I). The turnover rates (t 1/2) of 131I-HA were calculated from mono-exponential time-activity curves, obtained by external detection over ischemic and normally perfused areas during a 30 min period after IV injection of 0.7-1.5 mCi 131I-HA. The t 1/2 values in ischemic regions were found to be significantly longer (group II, 25.1 +/- 2.6 min; group III, 22.6 +/- 1.8 min) than in non-ischemic areas (group II, 12.5 +/- 1.8 min; group III, 14.2 +/- 1.4 min). The t 1/2 values in the control dogs (group I, 13.4 +/- 1.4 min) were not significantly different from the turnover rates in the non-ischemic areas of the occluded hearts. We conclude that the study of turnover rates of radioiodinated free fatty acids allows the determination of regional myocardial metabolism and offers a means to distinguish normally perfused from ischemic myocardial tissue.
E E van der Wall; G Westera; W den Hollander; F C Visser
Related Documents :
22893479 - Autonomic boundary conditions for ventricular fibrillation and their implications for a...
3440779 - Characterization of nonischemic segment shortening during variable extent of myocardial...
20960409 - Patent ductus arteriosus in dogs.
11753019 - Hyperglycemia prevents isoflurane-induced preconditioning against myocardial infarction.
6470339 - Retrograde coronary venous contrast echocardiography: assessment of shunting and deline...
22830029 - A model of left ventricular dysfunction complicated by caws arteritis in dba/2 mice.
9462599 - Prediction of death and neurologic outcome in the emergency department in out-of-hospit...
518779 - Comparative method for actuarial analysis of cardiac valve replacements.
2472519 - Reduction of myocardial damage and polymorphonuclear leukocyte accumulation following c...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of nuclear medicine     Volume:  6     ISSN:  0340-6997     ISO Abbreviation:  Eur J Nucl Med     Publication Date:  1981 Apr 
Date Detail:
Created Date:  1981-06-23     Completed Date:  1981-06-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7606882     Medline TA:  Eur J Nucl Med     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  147-51     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Coronary Disease / radionuclide imaging
Iodine Radioisotopes / diagnostic use*
Myocardium / metabolism*
Palmitic Acids / diagnostic use*
Reg. No./Substance:
0/Iodine Radioisotopes; 0/Palmitic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A mathematical model for the liver uptake and excretion of 99mTc-diethyl IDA.
Next Document:  Biologic gastric emptying time using Tc-99m TETA polystyrene resin in various clinical conditions.