Document Detail


External detection of pulmonary accumulation of indium-113m labelled transferrin in the guinea pig.
MedLine Citation:
PMID:  1699294     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Accumulation of radioisotope labelled transferrin in the lungs of guinea pigs was determined with an external detection system. The method is based on the intravascular and extravascular distribution of indium-113m labelled transferrin compared with the intravascular distribution of technetium-99m labelled red blood cells. Guinea pigs were given iloprost, a prostacyclin analogue and potent pulmonary vasodilator, and noradrenaline, a pulmonary vasoconstrictor, in an attempt to increase and decrease respectively the blood volume in the lungs. Neither agent altered transferrin accumulation in the lung by comparison with a saline infusion. Iloprost infused before and after oleic acid infusion reduced macro-molecular leakage when compared with oleic acid alone. These data suggest that the double isotope method can distinguish between hydrostatic and injury induced pulmonary oedema.
Authors:
U Hultkvist-Bengtsson; L Mårtensson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thorax     Volume:  45     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-11-19     Completed Date:  1990-11-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  688-93     Citation Subset:  IM    
Affiliation:
Department of Zoophysiology, University of Lund, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiovascular Agents / pharmacology
Erythrocytes
Guinea Pigs
Iloprost / pharmacology
Indium Radioisotopes / diagnostic use*
Lung / drug effects,  metabolism*,  radionuclide imaging
Male
Norepinephrine / pharmacology
Oleic Acid
Oleic Acids / pharmacology
Pulmonary Edema / metabolism*,  radionuclide imaging
Technetium / diagnostic use
Transferrin / metabolism*
Chemical
Reg. No./Substance:
0/Cardiovascular Agents; 0/Indium Radioisotopes; 0/Oleic Acids; 11096-37-0/Transferrin; 112-80-1/Oleic Acid; 51-41-2/Norepinephrine; 7440-26-8/Technetium; 78919-13-8/Iloprost
Comments/Corrections

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