Document Detail

External detection of pulmonary accumulation of indium-113m labelled transferrin in the guinea pig.
MedLine Citation:
PMID:  1699294     Owner:  NLM     Status:  MEDLINE    
Accumulation of radioisotope labelled transferrin in the lungs of guinea pigs was determined with an external detection system. The method is based on the intravascular and extravascular distribution of indium-113m labelled transferrin compared with the intravascular distribution of technetium-99m labelled red blood cells. Guinea pigs were given iloprost, a prostacyclin analogue and potent pulmonary vasodilator, and noradrenaline, a pulmonary vasoconstrictor, in an attempt to increase and decrease respectively the blood volume in the lungs. Neither agent altered transferrin accumulation in the lung by comparison with a saline infusion. Iloprost infused before and after oleic acid infusion reduced macro-molecular leakage when compared with oleic acid alone. These data suggest that the double isotope method can distinguish between hydrostatic and injury induced pulmonary oedema.
U Hultkvist-Bengtsson; L Mårtensson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thorax     Volume:  45     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-11-19     Completed Date:  1990-11-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  688-93     Citation Subset:  IM    
Department of Zoophysiology, University of Lund, Sweden.
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MeSH Terms
Cardiovascular Agents / pharmacology
Guinea Pigs
Iloprost / pharmacology
Indium Radioisotopes / diagnostic use*
Lung / drug effects,  metabolism*,  radionuclide imaging
Norepinephrine / pharmacology
Oleic Acid
Oleic Acids / pharmacology
Pulmonary Edema / metabolism*,  radionuclide imaging
Technetium / diagnostic use
Transferrin / metabolism*
Reg. No./Substance:
0/Cardiovascular Agents; 0/Indium Radioisotopes; 0/Oleic Acids; 11096-37-0/Transferrin; 112-80-1/Oleic Acid; 51-41-2/Norepinephrine; 7440-26-8/Technetium; 78919-13-8/Iloprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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