| External collar inhibits balloon-induced intimal hyperplasia in rabbits. | |
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MedLine Citation:
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PMID: 12187126 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intimal hyperplasia is a common complication following vascular interventions. To understand the underlying pathophysiology, the focus has mainly been on the intima and media. The adventitia has been less investigated, although adventitial hyperplasia is seen together with intimal hyperplasia. If the adventitial response is an important part of the process, the adventitia might be a target to inhibit intimal hyperplasia. In the present study we investigated whether an external collar attenuating the adventitial thickness could inhibit a balloon-induced intimal hyperplasia. The common carotid artery was injured in rabbits (n = 6) with a 3-french balloon catheter. The mid portion of the injured artery was encircled with a silicone collar (diameter = 2.0 mm). After 14 days the balloon-induced neointima was reduced by 54 +/- 6.3% underneath the collar. The adventitial and medial thickenings were also attenuated (36 +/- 8.7 and 44 +/- 4.3%, respectively). This study demonstrates that intimal hyperplasia following balloon injury can be inhibited with an external collar. This supports the idea of the adventitia as a potential target to inhibit intimal hyperplasia. |
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Authors:
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Per Fogelstrand; Bo Risberg; Erney Mattsson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of vascular research Volume: 39 ISSN: 1018-1172 ISO Abbreviation: J. Vasc. Res. Publication Date: 2002 Jul-Aug |
Date Detail:
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Created Date: 2002-08-20 Completed Date: 2002-09-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9206092 Medline TA: J Vasc Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 361-7 Citation Subset: IM |
Copyright Information:
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Copyright 2002 S. Karger AG, Basel |
Affiliation:
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Wallenberg Laboratory for Cardiovascular Research, Department of Vascular Surgery, Sahlgrenska University Hospital, Göteborg, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Actins
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analysis Animals Apoptosis Balloon Dilatation* Carotid Artery Injuries* Carotid Artery, Common / pathology Cell Count Cell Division Constriction Endothelium, Vascular / pathology Hyperplasia Immunohistochemistry Macrophages / pathology Male Myosin Heavy Chains / analysis Rabbits Tunica Intima / pathology* |
| Chemical | |
Reg. No./Substance:
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0/Actins; 0/Myosin Heavy Chains |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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