Document Detail


External beam radiation therapy for PTFE dialysis grafts: a pilot study.
MedLine Citation:
PMID:  22287221     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The aim of this study was to identify the effects of external beam radiation on PTFE dialysis graft dysfunction.
METHODS: Seven patients who underwent PTFE dialysis graft angioplasty were randomized to receive either two 8 Gy doses of external beam radiation or no radiation. The primary endpoint was time to graft thrombosis with a secondary endpoint of time to first intervention.
RESULTS: There was no statistically significant difference between the two groups in either of the endpoints, although grafts in the radiation group had a shorter time to thrombosis or intervention.
CONCLUSIONS: Our results demonstrate technical feasibility for use of external beam radiation in the setting of dialysis vascular access graft dysfunction. Larger randomized studies are required to identify whether there is a clinical benefit from this intervention.
Authors:
Prabir Roy-Chaudhury; Heather J Duncan; Darryl Zuckerman; Rashid Faiyaz; Rino Munda; Shashi Kant; Burnett Kelly; Ashwatha Narayana
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The journal of vascular access     Volume:  13     ISSN:  1724-6032     ISO Abbreviation:  J Vasc Access     Publication Date:    2012 Jul-Sep
Date Detail:
Created Date:  2012-10-01     Completed Date:  2013-03-01     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  100940729     Medline TA:  J Vasc Access     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  329-31     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Angioplasty*
Arteriovenous Shunt, Surgical / adverse effects,  instrumentation*
Blood Vessel Prosthesis*
Blood Vessel Prosthesis Implantation / adverse effects,  instrumentation*
Combined Modality Therapy
Constriction, Pathologic
Feasibility Studies
Graft Occlusion, Vascular / etiology,  radiotherapy,  therapy*
Humans
Middle Aged
Pilot Projects
Polytetrafluoroethylene / radiation effects*
Prosthesis Design
Radiation Dosage
Renal Dialysis*
Thrombosis / etiology
Time Factors
Treatment Outcome
Grant Support
ID/Acronym/Agency:
1R01DK088777/DK/NIDDK NIH HHS; 1R21-DK089280-01/DK/NIDDK NIH HHS; 5R01-EB004527/EB/NIBIB NIH HHS; 5U01-DK82218/DK/NIDDK NIH HHS; 5U01-DK82218S/DK/NIDDK NIH HHS; UL1 TR000077/TR/NCATS NIH HHS; UL1RR026314/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
9002-84-0/Polytetrafluoroethylene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  More evidence for a dual-process model of conditional reasoning.
Next Document:  Five years of vascular access stenosis surveillance by blood flow rate measurements during hemodialy...