Document Detail


External Validation of Extranodal Extension and Lymph Node Density as Predictors of Survival in Node-positive Bladder Cancer after Radical Cystectomy.
MedLine Citation:
PMID:  23208127     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Prognostic factors in pathologic node-positive patients after radical cystectomy are debated. Extranodal extension (ENE) and lymph node density (LND) are strong predictors of survival. The aim of this study was to assess factors predictive of survival and to evaluate the prognostic significance of the tumor, node, metastasis staging system (TNM) nodal classification in a retrospective cohort of node-positive bladder cancers after radical cystectomy. METHODS: We retrospectively reviewed the data of 75 patients with node-positive bladder cancer after radical cystectomy. Node pathological examination was performed by two experienced uropathologists. Cox regression analysis was performed to identify factors predictive of progression. RESULTS: The median number of removed lymph node was 18 (range 3-49). The median number of positive lymph nodes was 3 (range 1-35). Overall progression-free and cancer-specific survival were 5 and 12 %. In multivariate analysis, ENE, LND with a 20 % cutoff, and adjuvant chemotherapy were independent predictors of progression-free survival (p = 0.007, 0.006, <0.0001). Neither the 2002 nor the 2009 TNM nodal classification was associated with recurrence. CONCLUSIONS: ENE and LND are strong predictors of clinical outcome in patients with node-positive bladder cancer treated by cystectomy. The actual TNM classification could probably be improved using these criteria, allowing better prognostic classification of node-positive bladder cancer after radical cystectomy.
Authors:
Alexandra Masson-Lecomte; Dimitri Vordos; Andras Hoznek; René Yiou; Yves Allory; Claude C Abbou; Alexandre de la Taille; Laurent Salomon
Related Documents :
10028857 - Turkish experience with rhabdomyosarcoma: an analysis of 255 patients for 20 years.
23549007 - Reappraisal of pretreatment carcinoembryonic antigen in patients with rectal cancer rec...
24768477 - Prognostic, predictive abilities and concordance of bcl2 and tp53 protein expression in...
24288537 - Prognostic significance of serum free light chains in chronic lymphocytic leukemia.
2540577 - Surgical resection in the treatment of stages i-ii of small cell lung carcinoma (sclc).
24323027 - Breast implant-associated anaplastic large-cell lymphoma: long-term follow-up of 60 pat...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-4
Journal Detail:
Title:  Annals of surgical oncology     Volume:  -     ISSN:  1534-4681     ISO Abbreviation:  Ann. Surg. Oncol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9420840     Medline TA:  Ann Surg Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Urology, Henri Mondor Hospital, University Paris Est Créteil (Paris 12), Creteil, France, amassonlecomte@gmail.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Thoracoscopic Internal Mammary Lymph Node Dissection: A Video Demonstration.
Next Document:  KRAS Mutation in Patients with Lung Cancer: A Predictor for Poor Prognosis but Not for EGFR-TKIs or ...