Document Detail

Extent of autonomic activation following cerebral ischemia is different in hypertensive and normotensive humans.
MedLine Citation:
PMID:  8815854     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate whether the extent of autonomic activation following brain infarction differs between hypertensive and normotensive humans, and to investigate the role of the insular cortex for this sympathetic activation. DESIGN: Prospective, hospital-based study. SETTING: Department of Neurology of a university medical center. SUBJECTS: Forty-two patients with essential hypertension and 45 patients who were normotensive. MAIN OUTCOME MEASURES: Extent of autonomic activation following stroke as indicated by circadian blood pressure patterns, serum norepinephrine levels, and cardiovascular variables. RESULTS: Normotensive patients with insular infarction showed a significantly reduced circadian blood pressure variation and a higher frequency of nocturnal blood pressure increase compared with patients suffering from essential hypertension and insular stroke. These findings were also associated with higher serum norepinephrine concentrations and more frequent electrocardiographic abnormalities. No significant changes in these variables were seen between normotensive and hypertensive patients without insular involvement. CONCLUSIONS: Our findings suggest a difference in cortical control of autonomic function between hypertensive and normotensive patients after stroke and point to a possible role of the insular cortex in the pathogenesis of essential hypertension.
D Sander; J Klingelhöfer
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of neurology     Volume:  53     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1996-10-09     Completed Date:  1996-10-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  890-4     Citation Subset:  AIM; IM    
Department of Neurology, Technical University of Munich, Germany.
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MeSH Terms
Arrhythmias, Cardiac / physiopathology
Autonomic Nervous System / physiopathology*
Blood Pressure*
Brain Ischemia / complications,  physiopathology*,  radiography
Cerebral Infarction / complications,  physiopathology*,  radiography
Confidence Intervals
Hypertension / complications,  physiopathology*
Middle Aged
Multivariate Analysis
Norepinephrine / blood
Tomography, X-Ray Computed
Reg. No./Substance:

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