Document Detail


The extent of coronary atherosclerosis is associated with increasing circulating levels of high sensitive cardiac troponin T.
MedLine Citation:
PMID:  20299689     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: This study explored the relationship between coronary atherosclerotic plaque burden and quantifiable circulating levels of troponin measured with a recently introduced high sensitive cardiac troponin T (hs-cTnT) assay. METHODS AND RESULTS: Cardiac patients suspected of having coronary artery disease (CAD) but without acute coronary syndrome were studied. Cardiac troponin T levels were assessed using the fifth-generation hs-cTnT assay. All patients (n=615) underwent cardiac computed tomographic angiography (CCTA). On the basis of CCTA, patients were classified as having no CAD or mild (<50% lesion), moderate (50% to 70% lesion), severe (>70% lesion), or multivessel CAD (multiple >70% lesions). As a comparison, high-sensitivity C-reactive protein levels were measured. Progressively increasing hs-cTnT levels were found in patients with mild (median, 4.5 ng/L), moderate (median, 5.5 ng/L), severe (median, 5.7 ng/L), and multivessel (median, 8.6 ng/L) CAD compared with patients without CAD (median, 3.7 ng/L) (all P<0.01). For high-sensitivity C-reactive protein and N-terminal pro-B-type natriuretic peptide, no such relationship was observed. In patients without CAD, 11% showed hs-cTnT levels in the highest quartile, compared with 62% in the multivessel disease group (P<0.05). Multivariance analysis identified hs-cTnT as an independent risk factor for the presence of CAD. CONCLUSIONS: In patients without acute coronary syndrome, even mild CAD is associated with quantifiable circulating levels of hs-cTnT.
Authors:
Eduard M Laufer; Alma M A Mingels; Mark H M Winkens; Ivo A P G Joosen; Mark W M Schellings; Tim Leiner; Joachim E Wildberger; Jagat Narula; Marja P Van Dieijen-Visser; Leonard Hofstra
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-03-18
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  30     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-20     Completed Date:  2010-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1269-75     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biological Markers / blood
C-Reactive Protein / metabolism
Chi-Square Distribution
Coronary Angiography / methods
Coronary Stenosis / blood*,  etiology,  radiography
Female
Humans
Likelihood Functions
Logistic Models
Male
Middle Aged
Natriuretic Peptide, Brain / blood
Odds Ratio
Peptide Fragments / blood
Predictive Value of Tests
Risk Assessment
Risk Factors
Severity of Illness Index
Tomography, X-Ray Computed
Troponin T / blood*
Up-Regulation
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Peptide Fragments; 0/Troponin T; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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