Document Detail

Extensively drug-resistant tuberculosis in sub-Saharan Africa: an emerging public-health concern.
MedLine Citation:
PMID:  18243260     Owner:  NLM     Status:  MEDLINE    
The extensively drug-resistant tuberculosis (XDR-TB) categorisation has been developed as a phenotypic description of those TB strains that are resistant to most conventional anti-TB drugs. While widely accepted to have significant incidence in those areas, such as Eastern Europe, that have high levels of multidrug resistance, recent reports have described a cluster of XDR-TB cases in the KwaZulu-Natal province of South Africa. With very high case-fatality rates in this setting and a paucity of potential treatment options, concerns have grown about the possibility of an outbreak of highly lethal TB occurring in areas where TB prevalence, generally, is at its highest. In this article, we review previously documented case series of XDR-TB, and examine questions around the likelihood of rapid XDR-TB expansion in sub-Saharan Africa. We analyse how current TB control measures in the area might cope with such a challenge, and identify new areas for focus within the research and development community.
Kelsey D J Jones; Therese Hesketh; John Yudkin
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Transactions of the Royal Society of Tropical Medicine and Hygiene     Volume:  102     ISSN:  0035-9203     ISO Abbreviation:  Trans. R. Soc. Trop. Med. Hyg.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-18     Completed Date:  2008-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506129     Medline TA:  Trans R Soc Trop Med Hyg     Country:  England    
Other Details:
Languages:  eng     Pagination:  219-24     Citation Subset:  IM    
UCL Centre for International Health and Development, The Institute of Child Health, London, UK.
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MeSH Terms
Africa South of the Sahara / epidemiology
Antitubercular Agents / therapeutic use
Drug Resistance, Bacterial
Extensively Drug-Resistant Tuberculosis / epidemiology*,  prevention & control
Microbial Sensitivity Tests / methods
Mycobacterium tuberculosis / drug effects
Reg. No./Substance:
0/Antitubercular Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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