| Extensively drug-resistant tuberculosis: epidemiology and management challenges. | |
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MedLine Citation:
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PMID: 20674800 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Widespread global use of rifampin for 2 decades preceded the emergence of clinically significant multidrug-resistant tuberculosis (MDR-TB) in the early 1990s. The prevalence of MDR-TB has gradually increased such that it accounts for approximately 5% of the global case burden of disease (approximately half a million cases in 2007). Eclipsing this worrying trend is the widespread emergence of extensively drug-resistant TB (XDR-TB). This article reviews the insights provided by clinical and molecular epidemiology regarding global trends and transmission dynamics of XDR-TB, and the challenges clinicians have to face in diagnosing and managing cases of XDR-TB. The ethical and management dilemmas posed by recurrent defaulters, XDR-TB treatment failures, and isolation of incurable patients are also discussed. Given the past global trends in MDR-TB, if aggressive preventive and management strategies are not implemented, XDR-TB has the potential to severely cripple global control efforts of TB. |
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Authors:
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Keertan Dheda; Robin M Warren; Alimuddin Zumla; Martin P Grobusch |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Infectious disease clinics of North America Volume: 24 ISSN: 1557-9824 ISO Abbreviation: Infect. Dis. Clin. North Am. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-02 Completed Date: 2010-11-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804508 Medline TA: Infect Dis Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 705-25 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Lung Infection and Immunity Unit, Division of Pulmonology and Clinical Immunology & UCT Lung Institute, Department of Medicine, University of Cape Town, Cape Town, South Africa. keertan.dheda@uct.ac.za |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antitubercular Agents
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pharmacology*,
therapeutic use Bacterial Typing Techniques DNA Fingerprinting Disease Outbreaks* Extensively Drug-Resistant Tuberculosis / diagnosis, drug therapy*, epidemiology*, microbiology Genotype HIV Infections / complications Humans Mycobacterium tuberculosis / classification, drug effects*, genetics, isolation & purification* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antitubercular Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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